Analysis Tools
normal phenotype
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• Background Sensitivity: on a 129/Sv isogenic background, mice show no overt phenotype
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Allele Symbol Allele Name Allele ID |
Etl4Gt(6LSN)6029Gos gene trap 6029, Achim Gossler MGI:3624626 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: on a 129/Sv isogenic background, mice show no overt phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bends in notochord have been observed in E12.5 and 13.5 embryos
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• in postnatal mice, caudal vertebrae show distorted shapes and abnormal articulations compared to wild-type
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• in postnatal mice, caudal vertebrae show distorted shapes and abnormal articulations compared to wild-type
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• Background Sensitivity: one third of homozygotes on this hybrid background show tail kinks in caudal region; interbreeding of homozygotes increases penetrance to 50 to 70%
• Background Sensitivity: three C57BL/6 backcrosses to the isogenic mice results in an increased penetrance of the tail phenotype to 50% compared to isogenic homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mutants with mutations in cis have vertebral columns that are normal in appearance with normal numbers of vertebrae that are similar in size and morphology to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in mutants carrying mutations in cis, ventral ossification center in the axis is normal or only slightly reduced, and dens axis is partially or completely restored compared to mice with mutantions in trans
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• at E16.5, vertebral columns are severely malformed or completely deleted caudal to the sacral region in mutants with alleles in trans
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• in most cases, no dens axis is present (cranial protrusion of second cervical vertebra) at E16.5 in mutants with alleles in trans
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• mice show obvious defects at the upper lumbar levels by E16.5 in mutants with alleles in trans
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• some mice with the two mutations in cis show mild defects in sacral vertebrae, while remainder show defects exclusively in the caudal end of the vertebral column
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• at upper lumbar level, vertebral bodies are split ventrally; deletions or malformations in the dorsal portion of the vertebrae are present in lower lumbar level in mutants with alleles in trans
• dorsoventral diameter of the vertebral body of the axis is further reduced
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• tails of compound heterozygotes carrying the mutations in trans are shorter than Sd heterozygotes, whereas compound mutants carrying the mutations in cis have a similar tail length phenotype to Sd heterozygotes
• tail lengths fall into three groups: group 1 animals have no tails or short, filamentous tail remnants, group 2 animals have tails between 1 and 2 cm in length, and group 3 animals have tails longer than 2 cm
• 4%, 11%, and 85% of compound heterozygotes with mutations in cis fall into groups1, 2, and 3 respectively, while percentages of mutants with alleles in trans are 71, 26, and 3% respectively in groups 1, 2, and 3; thus tail length is increased when alleles are in cis and length is decreased when mutations are carried in trans
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• high rate (around 50%) of postnatal lethality is exhibited
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• defects are similar or slightly worsened in extent, compared to compound homozygotes with the mutations in trans
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• defects are similar or slightly worsened in extent, compared to compound homozygotes with the mutations in trans
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• mutants show tail length distribution similar to compound heterozygotes having mutations in trans
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• 4 of 6 males tested were infertile
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• mice show various urogenital system abnormalities
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• mice have hypotrophic kidneys
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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