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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rb1tm1.2Gfk
targeted mutation 1.2, Graham F Kay
MGI:3624441
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rb1tm1.2Gfk/Rb1tm1.2Gfk involves: 129T2/SvEms * C57BL/6 * SJL MGI:3624444
ht2
 		Rb1tm1.2Gfk/Rb1+ involves: 129T2/SvEms * C57BL/6 * SJL MGI:3624446


Genotype
MGI:3624444
hm1
Allelic
Composition		 Rb1tm1.2Gfk/Rb1tm1.2Gfk
Genetic
Background		 involves: 129T2/SvEms * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1.2Gfk mutation (0 available); any Rb1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:108628 )
• homozygotes are never viable




Genotype
MGI:3624446
ht2
Allelic
Composition		 Rb1tm1.2Gfk/Rb1+
Genetic
Background		 involves: 129T2/SvEms * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1.2Gfk mutation (0 available); any Rb1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:108628 )
• start to die with pituitary tumors around 9 months of age

neoplasm
increased tumor incidence ( J:108628 )
• pituitary tumors result in deaths starting around 9 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory