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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Espl1tm1.1Kna
targeted mutation 1.1, Kim Nasmyth
MGI:3624200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL MGI:5551815
cn2
 		Espl1tm1.1Kna/Espl1tm1.1Kna
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3625271


Genotype
MGI:5551815
cn1
Allelic
Composition		 Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (168 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:205429 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells




Genotype
MGI:3625271
cn2
Allelic
Composition		 Espl1tm1.1Kna/Espl1tm1.1Kna
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal hepatocyte morphology ( J:107916 )
• in cultured hepatocytes treated with poly(I)poly(C) 80% of anaphase cells have sister chromatids that fail to properly disjoin so that mitosis produces cells with micronuclei and abnormally large nuclei
abnormal liver regeneration ( J:107916 )
• after a injection with 400 ul poly(I)poly(C) and a two thirds hepatectomy, liver regeneration occurs but cells are larger, contain larger nuclei, and increased DNA content (many cell with 8C, 16C,or 32C DNA content) suggesting that regeneration occurs by genome replication without cell proliferation

hematopoietic system
decreased bone marrow cell number ( J:107916 )
• 3 days after a injection with 400 ul poly(I)poly(C) severe bone marrow aplasia is seen with only erythrocytes present; however, by 31 days after injection bone marrow cell numbers return to normal (all of these new hematopoeitic cells contain unrecombined alleles)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory