homeostasis/metabolism
• cold-exposed mice exhibit higher core body temperature than wild-type mice
• cold-exposed mice exhibit a greater increase in brown adipocyte-like regions in inguinal fat compared with wild-type mice
• however, resistance to hypothermia is abolished when the interscapular brown adipose tissue is removed
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• when housed at room temperature or cold exposed
• however, adenoviral expression of adiponectin abolishes the increased body temperature
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• at the onset of the dark phase
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• in the presence of the lipid substrate palmitoyl carnitine
• however, adenoviral expression of adiponectin reduces the rate
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adipose tissue
• cold-exposed mice exhibit a greater increase in brown adipocyte-like regions in inguinal fat compared with wild-type mice
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cellular
• reduced mitochondrial respiration without altering mitochondrial biogenesis
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