Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc6tm1Lbi mutation
(1 available);
any
Trpc6 mutation
(67 available)
|
|
|
vision/eye
|
|
• at one light intensity, intrinsically photosensitive retinal ganglion cells exhibit enhanced spike activity compared with wild-type cells
• M1 and M2 intrinsically photosensitive retinal ganglion cells exhibit reduced amplitude of response to light stimulation and inward current compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc6tm1Lbi mutation
(1 available);
any
Trpc6 mutation
(67 available)
|
|
|
cardiovascular system
|
|
• mean arterial blood pressure as measured by telemetric sensors is singificantly higher in homozygous mutant mice than in wild-type littermates; administration of a nitric oxide synthase inhibitor results in greater elevation of the blood pressure of mutant than of wild-type mice
|
|
|
• basal Ba2+ influx into single smooth muscle cells is greatly elevated in cells from thoracic aortae or cerebral aerteries of mutant mice versus from wild-type littermates, and increases further upon application of a diacylglycerol (DAG) analog; infection by adenovirus expressing siRNA against Trpc3 mRNA significantly diminishes the basal Ba2+ flux in mutant smooth muscle cells, but has no effect in wild-type cells
• whole-cell patch clamp recording of cerebral artery smooth muscle cells demonstrates higher basal current densities and a more depolarized membrane potential in mutant than in wild-type cells
|
|
|
• although intravascular pressure causes a similar degree of vasoconstriction of cerebral arteries from wild-type and mutant littermates, the pressure at which myogenic dilatation reverses to myogenic constriction is significantly lower in mutant arteries
|
|
|
• aortic rings and small mesenteric arteries from homozygous mutant mice are induced to greater contractility than are vessels from wild-type littermates by the alpha-1-adrenoreceptor agonist phenylephrine both in the absence and in the presence of the voltage-gated Ca2+ channel blocker CdCl2
|
muscle
|
|
• basal Ba2+ influx into single smooth muscle cells is greatly elevated in cells from thoracic aortae or cerebral aerteries of mutant mice versus from wild-type littermates, and increases further upon application of a diacylglycerol (DAG) analog; infection by adenovirus expressing siRNA against Trpc3 mRNA significantly diminishes the basal Ba2+ flux in mutant smooth muscle cells, but has no effect in wild-type cells
• whole-cell patch clamp recording of cerebral artery smooth muscle cells demonstrates higher basal current densities and a more depolarized membrane potential in mutant than in wild-type cells
|
|
|
• although intravascular pressure causes a similar degree of vasoconstriction of cerebral arteries from wild-type and mutant littermates, the pressure at which myogenic dilatation reverses to myogenic constriction is significantly lower in mutant arteries
|
|
|
• aortic rings and small mesenteric arteries from homozygous mutant mice are induced to greater contractility than are vessels from wild-type littermates by the alpha-1-adrenoreceptor agonist phenylephrine both in the absence and in the presence of the voltage-gated Ca2+ channel blocker CdCl2
|
nervous system
|
N |
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC
|
Analysis Tools