Analysis Tools
cellular
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• expression of one unfolded protein response target genes, Edem, is decreased in mouse embryonic fibroblasts stressed with tunicamycin or thapsigargin results
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Allele Symbol Allele Name Allele ID |
Ern1tm1Rjk targeted mutation 1, Randal J Kaufman MGI:3622330 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression of one unfolded protein response target genes, Edem, is decreased in mouse embryonic fibroblasts stressed with tunicamycin or thapsigargin results
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos die around E10.5
• Background Sensitivity: by backcrossing these heterozygotes further onto C57BL/6J, homozygous embryos which survive to E12.5-13 are produced
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• at E13 homozygotes exhibit growth retardation
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• by E13 homozygotes can be recognized by their small size
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• at E13 homozygotes exhibit growth retardation
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• by E13 homozygotes can be recognized by their small size
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• hematopoietic cells from null mice have a 2.5-fold lower rate of proliferation than the rate of heterozygous cell proliferation
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• Ern1-null pro-B cells are defective in VDJ recombination of immunoglobulin genes and do not express B cell receptors
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• Ern1-null pro-B cells are defective in VDJ recombination of immunoglobulin genes and do not express B cell receptors
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• at E12.5, homozygous fetal livers are markedly reduced in size compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5-times in response to Bortezomib treatment
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• following tamoxifen treatment
• following partial hepatectomy
• in response to Bortezomib treatment
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• liver cells exhibit less rough endoplasmic reticulum content compared with control liver cells
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• mice exhibit a slight increase in hepatic lipid content compared with control mice
• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice
• however, phospholipid synthesis is normal
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• mice exhibit a slight increase in hepatic lipid content compared with control mice
• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice
• however, phospholipid levels in the liver are normal
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• following tamoxifen-treatment
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• following tamoxifen treatment
• following partial hepatectomy
• in response to Bortezomib treatment
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• following tamoxifen-treatment, secretion of apolipoproteins from liver cells is decreased compared to in control mice
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• 5-times in response to Bortezomib treatment
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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