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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripk2tm1Cfl
targeted mutation 1, Chafen Lu
MGI:3622328
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ripk2tm1Cfl/Ripk2tm1Cfl involves: 129S5/SvEvBrd MGI:3625078


Genotype
MGI:3625078
hm1
Allelic
Composition		 Ripk2tm1Cfl/Ripk2tm1Cfl
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk2tm1Cfl mutation (0 available); any Ripk2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:107130 )
• lipopolysaccharide-induced TNFA and IL-6 production by macrophages is decreased compared to wild-type

hematopoietic system
abnormal macrophage physiology ( J:107130 )
• lipopolysaccharide-induced TNFA and IL-6 production by macrophages is decreased compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory