Ripk2^tm1Cfl
Targeted Allele Detail

Summary

• Symbol: Ripk2^tm1Cfl
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Chafen Lu
• MGI ID: MGI:3622328
• Gene: Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
• Alliance: Ripk2^tm1Cfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107130
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to remove a 204 bp fragment containing exon 1 that codes for the N-terminal sequences of protein, including the kinase active site lysine 47. Absence of transcript and protein were confirmed by Northern and Western blot, respectively. (J:107130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk2 Mutation: 34 strains or lines available

References

• Original: J:107130 Lu C, et al., Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity. J Biol Chem. 2005 Apr 22;280(16):16278-83
• All: 1 reference(s)