Phenotypes associated with this allele

• Allele Symbol: Tnks2^tm1.1Yjc
• Allele Name: targeted mutation 1.1, Y Jeffrey Chiang
• Allele ID: MGI:3621924
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv	MGI:3622054
cx2	Tnks^tm1.1Yjc/Tnks^tm1.1Yjc Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806325
cx3	Tnks^tm1.1Yjc/Tnks^+ Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806326

Genotype
MGI:3622054

hm1

• Allelic Composition: Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:106918 )

N • homozygotes give no indication of embryonic lethality

adipose tissue

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice

growth/size/body

decreased body weight ( J:106918 , J:137985 )

• lower weight in females seen primarily between weeks 5 and 13, weights at 42 weeks not significantly different from controls (J:106918)

• male weights 20% less than controls throughout 42 week observation period (J:106918)

cellular

cellular phenotype ( J:106918 , J:137985 )

N • no alteration in telomere length detected over the course of 7 generations (J:106918)

N • mice exhibit normal cell cycling, irradiation sensitivity and telomere length (J:137985)

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice

Genotype
MGI:3806325

cx2

• Allelic Composition: Tnks^tm1.1Yjc/Tnks^tm1.1Yjc; Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5

embryo

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

abnormal placenta morphology ( J:137985 )

decreased trophoblast giant cell number ( J:137985 )

absent umbilical cord blood vessels ( J:137985 )

• at E10.5, all mutant embryos show absence of umbilical vessels

absent umbilical cord ( J:137985 )

• at E10.5, mutant embryos lack an umbilical cord

growth/size/body

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

integument

pallor ( J:137985 )

• at E10.5, mutant embryos are pale compared to wild-type controls

Genotype
MGI:3806326

cx3

• Allelic Composition: Tnks^tm1.1Yjc/Tnks⁺; Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5