All Phenotypes Tnks2<tm1.1Yjc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnks2^tm1.1Yjc
targeted mutation 1.1, Y Jeffrey Chiang
MGI:3621924

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv	MGI:3622054
cx2	Tnks^tm1.1Yjc/Tnks^tm1.1Yjc Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806325
cx3	Tnks^tm1.1Yjc/Tnks⁺ Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806326

Allelic Composition	Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnks2^tm1.1Yjc mutation (1 available); any Tnks2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:106918 )

N	• homozygotes give no indication of embryonic lethality

adipose tissue

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice

growth/size/body

decreased body weight ( J:106918 , J:137985 )

• lower weight in females seen primarily between weeks 5 and 13, weights at 42 weeks not significantly different from controls (J:106918)

• male weights 20% less than controls throughout 42 week observation period (J:106918)

cellular

cellular phenotype ( J:106918 , J:137985 )

N	• no alteration in telomere length detected over the course of 7 generations (J:106918) • mice exhibit normal cell cycling, irradiation sensitivity and telomere length (J:137985)

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice

Allelic Composition	Tnks^tm1.1Yjc/Tnks^tm1.1Yjc Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnks2^tm1.1Yjc mutation (1 available); any Tnks2 mutation (48 available)
Tnks^tm1.1Yjc mutation (1 available); any Tnks mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5

embryo

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

abnormal placenta morphology ( J:137985 )

decreased trophoblast giant cell number ( J:137985 )

absent umbilical cord blood vessels ( J:137985 )

• at E10.5, all mutant embryos show absence of umbilical vessels

absent umbilical cord ( J:137985 )

• at E10.5, mutant embryos lack an umbilical cord

growth/size/body

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

integument

pallor ( J:137985 )

• at E10.5, mutant embryos are pale compared to wild-type controls

Allelic Composition	Tnks^tm1.1Yjc/Tnks⁺ Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5

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