Tnks^tm1.1Yjc
Targeted Allele Detail

Summary

• Symbol: Tnks^tm1.1Yjc
• Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; targeted mutation 1.1, Y Jeffrey Chiang
• MGI ID: MGI:3804704
• Synonyms: TANK1^-
• Gene: Tnks Location: Chr8:35296333-35432844 bp, - strand Genetic Position: Chr8, 21.16 cM
• Alliance: Tnks^tm1.1Yjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137985
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was removed by germ line, cre-mediated recombination. The absence of protein expression was confirmed by western blot analysis on testis, kidney and spleen extracts. (J:137985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnks Mutation: 79 strains or lines available

References

• Original: J:137985 Chiang YJ, et al., Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One. 2008;3(7):e2639
• All: 4 reference(s)