Phenotypes associated with this allele
Allelic
Composition |
Lrp4tm1Her/Lrp4tm1Her
|
|
Genetic
Background |
involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation
(1 available);
any
Lrp4 mutation
(97 available)
|
|
|
nervous system
|
|
• acetylcholine receptor density is reduced compared to in wild-type mice
• neuromuscular junction are smaller with reduced innervation compared to in wild-type mice
• however, neuromuscular synapses are present at E16.5
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation
(1 available);
any
Lrp4 mutation
(97 available)
|
|
|
craniofacial
|
|
• distinct grooved incisor labial surfaces
|
|
|
• over one third show supernumerary maxillary incisor tooth germs at birth
|
|
|
• grooves on incisors result from a localized reduction of enamel on the labial surface
|
growth/size/body
|
|
• distinct grooved incisor labial surfaces
|
|
|
• over one third show supernumerary maxillary incisor tooth germs at birth
|
|
|
• grooves on incisors result from a localized reduction of enamel on the labial surface
|
skeleton
|
|
• distinct grooved incisor labial surfaces
|
|
|
• over one third show supernumerary maxillary incisor tooth germs at birth
|
|
|
• grooves on incisors result from a localized reduction of enamel on the labial surface
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation
(1 available);
any
Lrp4 mutation
(97 available)
|
|
|
mortality/aging
|
|
• number of homozygotes identified at P5 is much lower than expected, but up to approximately E13, numbers of each genotype is as expected
|
embryo
|
|
• the Fgf8-expressing AER is thickened and broadened in mutants
|
growth/size/body
|
|
• mutants have mild craniofacial defects usually in the form of incisor defects
|
|
|
• homozygotes show significantly reduced body weights and postnatal growth compared with wild-type and heterozygotes
|
limbs/digits/tail
|
|
• the Fgf8-expressing AER is thickened and broadened in mutants
|
|
|
• examination 14 day-old mutants revealed fused digital bones and tendons, club-shaped deformities of digital tips and metaphyseal defects
|
|
|
• homozygous mice have fully penetrant polysyndactyly of both the fore- and hindlimbs;
|
|
|
• extensive bone fusion can be seen in the forelimb
|
|
|
• extensive bone fusion can be seen in the hindlimb
|
craniofacial
|
|
• mutants have mild craniofacial defects usually in the form of incisor defects
|
skeleton
|
|
• mutants have mild craniofacial defects usually in the form of incisor defects
|
|
|
• at E12.5, chondrocye compaction is apparent in the fore- and hindlimbs of mutants; the digital cartilage is broadly fused in mutants as seen at P0
|
mortality/aging
|
|
• 20 of 49 mice die within 5 months
|
mortality/aging
|
|
• 6 of 45 mice die within 5 months
|
mortality/aging
|
|
• despite Mendelian ratios at E18.5, fewer than expected mice are present at weaning
|
nervous system
|
|
• increased nerve terminal sprouting
|
|
|
• reduced size and density of acetylcholine clusters compared with either single homozygote
|
cellular
|
|
• increased nerve terminal sprouting
|
mortality/aging
nervous system
Analysis Tools