Phenotypes associated with this allele

• Allele Symbol: Tnks2^tm1.1Susm
• Allele Name: targeted mutation 1.1, Susan Smith
• Allele ID: MGI:3621820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnks2^tm1.1Susm/Tnks2^tm1.1Susm	involves: 129S/SvEv * C57BL/6	MGI:3622156
ht2	Tnks2^tm1.1Susm/Tnks2^+	involves: 129S/SvEv * C57BL/6	MGI:3622157

Genotype
MGI:3622156

hm1

• Allelic Composition: Tnks2^tm1.1Susm/Tnks2^tm1.1Susm
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:106917 )

• 11 of 20 homozygotes die by P20 compared to 6 of 33 and 2 of 35 for heterozygous and wild-type mice, respectively

growth/size/body

decreased body weight ( J:106917 )

• on average homozygotes weigh less than wild-type mice and the number of severely affected mice is increased about 2-fold compared to Tnks2^tm1Susm homozygotes

cellular

cellular phenotype ( J:106917 )

N • telomere length and the incidence of chromosome aberrations in splenocytes and thymocytes is similar to wild-type

Genotype
MGI:3622157

ht2

• Allelic Composition: Tnks2^tm1.1Susm/Tnks2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:106917 )

• 6 of 33 heterozygotes die by P20 compared to 2 of 35 wild-type mice