Tnks2^tm1.1Susm
Targeted Allele Detail

Summary

• Symbol: Tnks2^tm1.1Susm
• Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; targeted mutation 1.1, Susan Smith
• MGI ID: MGI:3621820
• Synonyms: Tnks^{Pddeltaneodelta}
• Gene: Tnks2 Location: Chr19:36811632-36870877 bp, + strand Genetic Position: Chr19, 31.96 cM
• Alliance: Tnks2^tm1.1Susm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 25-27, encoding the PARP domain, with a neomycin resistance cassette. The vector was designed using the exon nomenclature in J:71663. The neo was removed via cre mediated recombination. This allele was expected to produce a null, however, truncated protein was detected. (J:106917)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnks2 Mutation: 48 strains or lines available

References

• Original: J:106917 Hsiao SJ, et al., Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol. 2006 Mar;26(6):2044-54
• All: 1 reference(s)