Phenotypes associated with this allele

• Allele Symbol: Krt4^tm1Rak
• Allele Name: targeted mutation 1, Raju Kucherlapati
• Allele ID: MGI:3620120
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt4^tm1Rak/Krt4^tm1Rak	involves: 129/Sv * C57BL/6J * SJL	MGI:3620123

Genotype
MGI:3620123

hm1

• Allelic Composition: Krt4^tm1Rak/Krt4^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Krt4^tm1Rak/Krt4^tm1Rak mice exhibit abnormalities of multiple epithelial tissues

digestive/alimentary system

abnormal tongue epithelium morphology ( J:49737 )

• tongue normal at 2 months of age but cellular hyperplasia seen on the ventral surface only at 5 months of age

• interdigitations into the submucosa similar to those seen on the dorsal surface

• cell proliferation found throughout the tongue epithelium rather than being restricted only to the basal layer

abnormal esophageal epithelium morphology ( J:49737 )

• overall thickening of the epithelium with little cell differentiation

• suprabasal layers with abnormal nuclei and a clear area surrounding the nucleus

• reduced keratohyalin granules

• diffuse and disorganized keratin layer becoming more disorganized from 2 to 5 months

esophageal epithelium hyperplasia ( J:49737 )

• in the basal epithelial layer with abnormal, enlarged nuclei having large nucleoli

• cell proliferation found throughout the esophageal epithelium rather than being restricted only to the basal layer

abnormal stomach epithelium morphology ( J:49737 )

• increased basal layer cellularity in the forestomach at 2 and 5 months of age

vision/eye

abnormal cornea epithelium morphology ( J:49737 )

• thickened with basal cell hyperplasia and abnormal nuclear morphology seen at 2 months

increased cornea epithelium thickness ( J:49737 )

cornea epithelium hyperplasia ( J:49737 )

pigmentation

abnormal skin pigmentation ( J:49737 )

• age dependent increase in melanin deposition

craniofacial

abnormal tongue epithelium morphology ( J:49737 )

• tongue normal at 2 months of age but cellular hyperplasia seen on the ventral surface only at 5 months of age

• interdigitations into the submucosa similar to those seen on the dorsal surface

• cell proliferation found throughout the tongue epithelium rather than being restricted only to the basal layer

integument

abnormal dermal layer morphology ( J:49737 )

• age dependent increase in melanin deposition

abnormal skin pigmentation ( J:49737 )

• age dependent increase in melanin deposition

growth/size/body

abnormal tongue epithelium morphology ( J:49737 )

• tongue normal at 2 months of age but cellular hyperplasia seen on the ventral surface only at 5 months of age

• interdigitations into the submucosa similar to those seen on the dorsal surface

• cell proliferation found throughout the tongue epithelium rather than being restricted only to the basal layer