Phenotypes associated with this allele

• Allele Symbol: Slfn14⁺
• Allele Name: wild type
• Allele ID: MGI:3619934
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slfn14^em1Nvm/Slfn14^+	C57BL/6J-Slfn14^em1Nvm	MGI:7286191

Genotype
MGI:7286191

ht1

• Allelic Composition: Slfn14^em1Nvm/Slfn14⁺
• Genetic Background: C57BL/6J-Slfn14^em1Nvm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:325381 )

• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia

increased spleen weight ( J:325381 )

• increase in spleen weight and size

abnormal erythropoiesis ( J:325381 )

• mice show differences in erythroid progenitors in the spleen and bone marrow, indicating upregulation of erythropoiesis

extramedullary hematopoiesis ( J:325381 )

• spleen is a secondary site for erythropoiesis; intermediate progenitors (EryBs) differentiate into mature erythrocytes (EryCs), which are highly populated within the spleen, suggesting erythroid maturation from the intermediate progenitor within the spleen

hemolytic anemia ( J:325381 )

abnormal proerythroblast morphology ( J:325381 )

• increase in the proportion of proerythroblasts in the spleen

increased erythrocyte cell number ( J:325381 )

• mice exhibit microcytic erythrocytosis, an increase in erythrocyte count accompanied by a reduction in size

decreased hemoglobin content ( J:325381 )

• lower hemoglobin levels

microcytosis ( J:325381 )

• mice exhibit microcytic erythrocytosis, an increase in erythrocyte count accompanied by a reduction in size

• irregularly shaped smaller erythrocytes (poikilocytes and microcytes)

• however, no difference in leukocyte counts

abnormal platelet morphology ( J:325381 )

• mice show a 15% increase in the proportion of CD41+ SYTO13+ cells, indicating an increase in the proportion of immature platelets

• however, mice exhibit normal platelet function in response to major agonists thrombin, collagen, and collagen-related peptide and normal platelet adhesion and spreading

increased mean platelet volume ( J:325381 )

• increase in platelet size

• however, no difference in platelet count is seen

increased megakaryocyte-erythroid progenitor cell number ( J:325381 )

• almost 3-fold increase in megakaryocyte-erythroid progenitors

• however, megakaryocyte counts in spleen are normal and the proportion of megakaryocytes is unchanged

homeostasis/metabolism

abnormal thrombosis ( J:325381 )

• following laser injury, mice form thrombi at a similar rate as controls, although they are smaller, with fewer platelets recruited, and embolize more quickly than in controls

• FeCl3 injury to the carotid artery results in occlusive thrombus formation as in wild-type mice, however mutants form thrombi at a slightly slower rate and have a tendency for reduced stability but not significantly

• however, mice exhibit normal bleeding times with tail tip excision and normal clot retraction

immune system

enlarged spleen ( J:325381 )

• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia

increased spleen weight ( J:325381 )

• increase in spleen weight and size

growth/size/body

enlarged spleen ( J:325381 )

• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia

increased spleen weight ( J:325381 )

• increase in spleen weight and size