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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Terf2tm1.1Tdl
targeted mutation 1.1, Titia de Lange
MGI:3619525
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Terf2tm1.1Tdl/Terf2tm1.1Tdl involves: 129P2/OlaHsd * C57BL/6 MGI:3619847
cn2
 		Terf2tm1Tdl/Terf2tm1.1Tdl
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3700173


Genotype
MGI:3619847
hm1
Allelic
Composition		 Terf2tm1.1Tdl/Terf2tm1.1Tdl
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf2tm1.1Tdl mutation (0 available); any Terf2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:105516 )
• lethality occurs sometime before E13.5




Genotype
MGI:3700173
cn2
Allelic
Composition		 Terf2tm1Tdl/Terf2tm1.1Tdl
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf2tm1.1Tdl mutation (0 available); any Terf2 mutation (28 available)
Terf2tm1Tdl mutation (1 available); any Terf2 mutation (28 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:112957 )
• following pI-pC injection to induce cre expression, telomeres undergo end-to-end fusions in quiescent hepatocytes, indicating telomere deprotection, however, hepatocytes are resistant to this damage and are functional in the presence of chromosome end fusions as indicated by normal liver function
• the telomere fusions seen in mutants do not impair liver regeneration after partial hepatectomy as regeneration occurs without cell division involving endoreduplication and cell growth, circumventing the chromosome segregation problems associated with telomere fusions

liver/biliary system
abnormal hepatocyte morphology ( J:112957 )
• following pI-pC injection to induce cre expression, telomeres undergo end-to-end fusions in quiescent hepatocytes, indicating telomere deprotection, however, hepatocytes are resistant to this damage and are functional in the presence of chromosome end fusions as indicated by normal liver function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory