All Phenotypes Tg(GFAP-TVA)10Ech MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(GFAP-TVA)10Ech
transgene insertion 10, Eric C Holland
MGI:3619228

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(GFAP-TVA)10Ech/0	involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL	MGI:3835350
tg2	Tg(GFAP-TVA)10Ech/0	involves: 129 * BALB/c * C57BL/6 * FVB/N	MGI:3835349

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(GFAP-TVA)10Ech/0
Genetic Background	involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (3 available); any Cdkn2a mutation (59 available)
Tg(GFAP-TVA)10Ech mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased glioma incidence ( J:52161 )

• 2 of 6 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

hydrocephaly ( J:52161 )

• at 6 weeks, mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop hydrocephalus

neoplasm

increased glioma incidence ( J:52161 )

• 2 of 6 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

Allelic Composition	Tg(GFAP-TVA)10Ech/0
Genetic Background	involves: 129 * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:52161 )

N	• mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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