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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ssbtm1Rjma
targeted mutation 1, Richard J Maraia
MGI:3617648
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ssbtm1Rjma/Ssbtm1Rjma involves: 129S/SvEv * C57BL/6 MGI:3618328
cn2
 		Ssbtm1Rjma/Ssbtm2.1Rjma
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S/SvEv * BALB/c MGI:5569496
cn3
 		Ssbtm1Rjma/Ssbtm2.1Rjma
Tg(Camk2a-cre)T29-1Stl/0 		involves: 129S/SvEv * BALB/c * C57BL * C57BL/6 MGI:5569497


Genotype
MGI:3618328
hm1
Allelic
Composition		 Ssbtm1Rjma/Ssbtm1Rjma
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbtm1Rjma mutation (0 available); any Ssb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:105552 )
• no homozygotes detected from E6.0 onward
• possible that death occurs before implantation

embryo
inner cell mass degeneration ( J:105552 )
• inner cell mass begins to degenerate starting after E3.0
abnormal trophoblast giant cell morphology ( J:105552 )
• trophoblast more persistent than inner cell mass but cell nuclei smaller than controls




Genotype
MGI:5569496
cn2
Allelic
Composition		 Ssbtm1Rjma/Ssbtm2.1Rjma
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S/SvEv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Ssbtm1Rjma mutation (0 available); any Ssb mutation (32 available)
Ssbtm2.1Rjma mutation (0 available); any Ssb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207687 )
N
• mice exhibit normal splenic CD4+ and CD8+ T cells
arrested B cell differentiation ( J:207687 )
• total block at the pro-B cell to pre-B cell transition
small spleen ( J:207687 )
• hyposplenia

hematopoietic system
arrested B cell differentiation ( J:207687 )
• total block at the pro-B cell to pre-B cell transition
small spleen ( J:207687 )
• hyposplenia




Genotype
MGI:5569497
cn3
Allelic
Composition		 Ssbtm1Rjma/Ssbtm2.1Rjma
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbtm1Rjma mutation (0 available); any Ssb mutation (32 available)
Ssbtm2.1Rjma mutation (0 available); any Ssb mutation (32 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased brain weight ( J:207687 )
• after 5 weeks
• rapid decline from 13 to 25 weeks, slowed decline afterward
• at 59 to 79 weeks
decreased forebrain size ( J:207687 )
• postnatal loss of forebrain mass at 16 and 32 weeks
forebrain hypoplasia ( J:207687 )
• progressive cell loss
abnormal cerebral cortex morphology ( J:207687 )
• loss of cortical cytoarchitecture at 16 and 32 weeks
thin cerebral cortex ( J:207687 )
• progressive neurodegeneration in the cerebral cortex (starting at 16 weeks) and hippocampus starting
• severely diminished at 65 weeks
abnormal neuron morphology ( J:207687 )
• decrease in neuronal density at 16 and 32 weeks
hippocampus pyramidal cell degeneration ( J:207687 )
• in the CA1 and subiculum
• however, the CA3 and dentate gyrus are relatively spared
neurodegeneration ( J:207687 )
• progressive neurodegeneration in the cerebral cortex and hippocampus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory