About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mt1-Ptch1)MT22Mps
transgene insertion MT22, Matthew P Scott
MGI:3617013
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617155
cx2
 		Hhiptm1Amc/Hhip+
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617156
cx3
 		Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617157


Genotype
MGI:3617155
cx1
Allelic
Composition		 Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal diencephalon morphology ( J:94269 )
• look normal at E10.5 except for a slight overgrowth in the diencephalon
abnormal neuronal precursor cell number ( J:94269 )
• ventral neuronal precursor population 2X controls, other precursor populations normal

embryo




Genotype
MGI:3617156
cx2
Allelic
Composition		 Hhiptm1Amc/Hhip+
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhiptm1Amc mutation (1 available); any Hhip mutation (43 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:94269 )
• or exencephaly present
exencephaly ( J:94269 )
• or spina bifida present
abnormal neuronal precursor cell number ( J:94269 )
• ventral neuronal precursor population expanded considerably

craniofacial
small first pharyngeal arch ( J:94269 )
• hyperplastic first branchial arch

embryo
small first pharyngeal arch ( J:94269 )
• hyperplastic first branchial arch
spina bifida ( J:94269 )
• or exencephaly present




Genotype
MGI:3617157
cx3
Allelic
Composition		 Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhiptm1Amc mutation (1 available); any Hhip mutation (43 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neural tube morphology ( J:94269 )
• ventral neuronal precursor population expanded and dorsal precursors decreased
enlarged floor plate ( J:94269 )
• 3X size of controls
incomplete rostral neuropore closure ( J:94269 )
• brain entirely open
abnormal neuronal precursor cell number ( J:94269 )
• entral neuronal precursor population expanded and dorsal precursors decreased

craniofacial
enlarged first pharyngeal arch ( J:94269 )
• first branchial arch considerably enlarged

vision/eye

embryo
enlarged first pharyngeal arch ( J:94269 )
• first branchial arch considerably enlarged
abnormal neural tube morphology ( J:94269 )
• ventral neuronal precursor population expanded and dorsal precursors decreased
enlarged floor plate ( J:94269 )
• 3X size of controls
incomplete rostral neuropore closure ( J:94269 )
• brain entirely open




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory