Phenotypes associated with this allele

• Allele Symbol: Tnf^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3616888
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^M1Btlr/Tnf^M1Btlr	C57BL/6J-Tnf^M1Btlr	MGI:3722937
ht2	Tnf^M1Btlr/Tnf^+	C57BL/6J-Tnf^M1Btlr	MGI:3722938

Genotype
MGI:3722937

hm1

• Allelic Composition: Tnf^M1Btlr/Tnf^M1Btlr
• Genetic Background: C57BL/6J-Tnf^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:124642 )

N • number and morphology of Peyer's patches and formation of germinal centers in the spleen are similar to wild-type mice, unlike in Tnf^tm1Gkl homozygotes

decreased follicular dendritic cell number ( J:124642 )

• upon immunization with a T cell antigen, there are a reduced number of follicular dendritic cells in the spleen

increased susceptibility to bacterial infection ( J:124642 )

• 7 days after a sublethal dose of Listeria monocytogenes, only 10% of mice survive compared to 60% for wild-type mice and 0% for Tnf^tm1Gkl homozygous mi

Genotype
MGI:3722938

ht2

• Allelic Composition: Tnf^M1Btlr/Tnf⁺
• Genetic Background: C57BL/6J-Tnf^M1Btlr

immune system

immune system phenotype ( J:124642 )

N • number and morphology of Peyer's patches, formation of germinal centers in the spleen, and survival after sublethal infection with Listeria monocytogenes are all similar to wild-type mice, unlike in Tnf^tm1Gkl homozygotes

decreased follicular dendritic cell number ( J:124642 )

• upon immunization with a T cell antigen, there are a reduced number of follicular dendritic cells in the spleen