Phenotypes associated with this allele

• Allele Symbol: Del(2Hoxd10-Hoxd13)7Ddu
• Allele Name: deletion, Chr 2, Denis Duboule 7
• Allele ID: MGI:3616161
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu	involves: 129S2/SvPas	MGI:3616438
cn2	Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu Hoxa^tm1Ddu/Del(6Hoxa)1Ddu Tg(Prrx1-cre)1Cjt/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3715858

Genotype
MGI:3616438

hm1

• Allelic Composition: Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hindlimb paralysis ( J:103924 )

• complete hindlimb paralysis

nervous system

abnormal ventral spinal root morphology ( J:103924 )

• reduced dorso-lumbar plexus

• absent peroneal branch from dorso-lumbar plexus

• no dorso-sacral plexus

muscle

muscular atrophy ( J:103924 )

• severe atrophy of anterolateral leg compartment muscles

Genotype
MGI:3715858

cn2

• Allelic Composition: Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu; Hoxa^tm1Ddu/Del(6Hoxa)1Ddu; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

limbs/digits/tail

abnormal forelimb zeugopod morphology ( J:114566 )

• no genuine forearm in newborn mice

absent radius ( J:114566 )

absent ulna ( J:114566 )

abnormal limb development ( J:114566 )

• abnormal segmented cartilaginous condensation is present, instead of digits, radii, or ulnae

abnormal digit development ( J:114566 )

• no genuine digits form on forelimb in newborn mice

skeleton

absent radius ( J:114566 )

absent ulna ( J:114566 )