Hoxa^tm1Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxa^tm1Ddu
• Name: homeobox A cluster; targeted mutation 1, Denis Duboule
• MGI ID: MGI:3583652
• Synonyms: HoxA^flox
• Gene: Hoxa Location: unknown Genetic Position: Chr6, cytoband B3-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted downstream of Hoxa1 and upstream of Hoxa13 to flank the entire region. (J:99350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa Mutation: 0 strains or lines available

Notes

Cre excision of the region between the two inserted loxP sites results in creation of Del(6Hoxa)1Ddu.

References

• Original: J:99350 Kmita M, et al., Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature. 2005 Jun 23;435(7045):1113-6
• All: 14 reference(s)