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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dsc3tm1Pko
targeted mutation 1, Peter J Koch
MGI:3615340
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dsc3tm1Pko/Dsc3tm1Pko involves: 129S6/SvEvTac * C57BL/6 MGI:3617824
ht2
 		Dsc3tm1Pko/Dsc3+ involves: 129S6/SvEvTac * C57BL/6 MGI:3617825


Genotype
MGI:3617824
hm1
Allelic
Composition		 Dsc3tm1Pko/Dsc3tm1Pko
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsc3tm1Pko mutation (0 available); any Dsc3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:105239 )
• homozygous embryos die around the 8 cell stage before compaction is complete




Genotype
MGI:3617825
ht2
Allelic
Composition		 Dsc3tm1Pko/Dsc3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsc3tm1Pko mutation (0 available); any Dsc3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:105239 )
• heterozygotes are viable and fertile with normal body weight and skin, tongue, palate, esophagus, and forestomach morphology
• epidermal development and keratinocyte differentiation are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory