Dsc3^tm1Pko
Targeted Allele Detail

Summary

• Symbol: Dsc3^tm1Pko
• Name: desmocollin 3; targeted mutation 1, Peter J Koch
• MGI ID: MGI:3615340
• Synonyms: Dsc3^-
• Gene: Dsc3 Location: Chr18:20093987-20135408 bp, - strand Genetic Position: Chr18, 11.11 cM
• Alliance: Dsc3^tm1Pko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105239
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo cassette replaced part of the promoter, exon 1 (containing the start codon) and intron 1. Quantitative PCR and Western blot analysis demonstrated that expression in heterozygous mice is half that of wild-type mice. (J:105239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsc3 Mutation: 48 strains or lines available

References

• Original: J:105239 Den Z, et al., Desmocollin 3 is required for pre-implantation development of the mouse embryo. J Cell Sci. 2006 Feb 1;119(Pt 3):482-9
• All: 1 reference(s)