All Phenotypes Bhlha15<tm2(Kras)Skz> MGI Mouse

mortality/aging

premature death ( J:105076 )

• mutants have a median survival of 10.8 months compared to the median survival of 24.2 months shown by wild-type

growth/size/body

cachexia ( J:105076 )

• starting at 3 months of age, mice become cachexic

enlarged liver ( J:105076 )

• mice often exhibit hepatomegaly

homeostasis/metabolism

hemorrhagic ascites ( J:105076 )

• starting at 3 months of age, mice present with hemorrhagic ascites

neoplasm

increased tumor incidence ( J:105076 )

• necropsy shows large primary tumors and numerous metastases that are solid and cystic in nature and up to several centimeters in diameter on visceral organs and the intraperitoneal space

increased pancreas adenoma incidence ( J:105076 )

• in 2 month old mice, solid or cystic pancreatic adenoma are observed

increased pancreatic acinar cell carcinoma incidence ( J:105076 )

• pancreatic cancer found in mutants is predominantly invasive acinar cell carcinoma; mixed carcinomas with acinar and ductal features are observed

increased hepatocellular carcinoma incidence ( J:105076 )

• mice show an increased incidence of this type compared to wild-type

increased liver adenoma incidence ( J:105076 )

• mutant mice are often found to have multifocal hepatocellular adenomas

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:105076 )

• metaplastic ductal structures are observed throughout the pancreas in close association with metaplastic acini

pancreatic acinar hyperplasia ( J:105076 )

• newborn and adult mice show acinar hyperplasia