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Allele Symbol Allele Name Allele ID |
Rettm11(RET)Jmi targeted mutation 11, Jeffrey Milbrandt MGI:3614441 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all die by 5 weeks of age
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• show an increase in apoptosis in the kidney at E15.5
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• renal parenchyma is decreased and homozygotes exhibit histopathological changes consistent with obstructive nephropathy
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• multiple cysts of varying sizes are observed at birth as well as later times
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• globally sclerosed glomeruli, indicating end-stage renal histology
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• severe reduction in the number of glomeruli
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• kidneys fail to establish an outer cortex region
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• kidneys fail to establish a normal architecture
• developing glomeruli are seen in embryos but they are scant and scattered throughout the mesenchyme
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• kidneys fail to establish an inner medulla region
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• ectopic kidney is seen by E15.5
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• severe dilation of both ureters
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• distal obstruction in postnatal mice, most likely due to the inability of ureters to separate from the wolffian duct
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• bilateral megaureters with distal stenosis are seen at birth
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• severe decrease in the branching morphogenesis of the ureteric buds
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• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct
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• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
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• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters
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• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
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• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters
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• show an increase in apoptosis in the kidney at E15.5
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• multiple cysts of varying sizes are observed at birth as well as later times
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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