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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abi1tm1Pen
targeted mutation 1, Ann Marie Pendergast
MGI:3613611
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abi1tm1Pen/Abi1tm1Pen involves: C57BL/6 MGI:4941221
hm2
 		Abi1tm1Pen/Abi1tm1Pen involves: CD-1 MGI:4941220
hm3
 		Abi1tm1Pen/Abi1tm1Pen Not Specified MGI:4358258
cx4
 		Abi1tm1Pen/Abi1+
Abi2tm1Pen/Abi2tm1Pen 		Not Specified MGI:4358259
cx5
 		Abi1tm1Pen/Abi1tm1Pen
Abi2tm1Pen/Abi2+ 		Not Specified MGI:4941219


Genotype
MGI:4941221
hm1
Allelic
Composition		 Abi1tm1Pen/Abi1tm1Pen
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abi1tm1Pen mutation (0 available); any Abi1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:169009 )
• mice die between E8.5 and E11.5

embryo
abnormal chorion morphology ( J:169009 )
• impaired vasculogenesis is indicated by the allantois that appears compact and lacks spaces at the distal tip compared to in wild-type mice

cardiovascular system
abnormal vasculogenesis ( J:169009 )
• impaired vasculogenesis is indicated by the allantois that appears compact and lacks spaces at the distal tip compared to in wild-type mice

growth/size/body
embryonic growth retardation ( J:169009 )
• at E8.5




Genotype
MGI:4941220
hm2
Allelic
Composition		 Abi1tm1Pen/Abi1tm1Pen
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abi1tm1Pen mutation (0 available); any Abi1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
decreased angiogenesis ( J:169009 )
• in the yolk sac
abnormal vitelline vasculature morphology ( J:169009 )
• mice exhibit reduced angiogenesis in the yolk sac compared with wild-type mice
abnormal heart layer morphology ( J:169009 )
• disrupted at E10.5
internal hemorrhage ( J:169009 )
• around the heart

embryo
abnormal vitelline vasculature morphology ( J:169009 )
• mice exhibit reduced angiogenesis in the yolk sac compared with wild-type mice
abnormal chorion morphology ( J:169009 )
• by E9.5, the chorion appears compact and button-like unlike in wild-type mice
increased Reichert's membrane thickness ( J:169009 )
• the basement membrane associated with Reichert's membrane is thickened compared to in wild-type mice

growth/size/body
embryonic growth retardation ( J:169009 )
• at E9.5

homeostasis/metabolism
edema ( J:169009 )
• around the heart

muscle




Genotype
MGI:4358258
hm3
Allelic
Composition		 Abi1tm1Pen/Abi1tm1Pen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abi1tm1Pen mutation (0 available); any Abi1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4358259
cx4
Allelic
Composition		 Abi1tm1Pen/Abi1+
Abi2tm1Pen/Abi2tm1Pen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abi1tm1Pen mutation (0 available); any Abi1 mutation (80 available)
Abi2tm1Pen mutation (0 available); any Abi2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:104623 )
• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells
• however, treatment with IL2 partially restores primary T cell proliferation
• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12

immune system
decreased T cell proliferation ( J:104623 )
• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells
• however, treatment with IL2 partially restores primary T cell proliferation
• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12
decreased interleukin-2 secretion ( J:104623 )
• when T cells are stimulated with anti-CD3 mediated

cellular
decreased T cell proliferation ( J:104623 )
• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells
• however, treatment with IL2 partially restores primary T cell proliferation
• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12




Genotype
MGI:4941219
cx5
Allelic
Composition		 Abi1tm1Pen/Abi1tm1Pen
Abi2tm1Pen/Abi2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abi1tm1Pen mutation (0 available); any Abi1 mutation (80 available)
Abi2tm1Pen mutation (0 available); any Abi2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:169009 )
• mouse embryonic fibroblasts exhibit defective spreading on fibronectin compared with wild-type cells




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory