Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
Tg(Gria2*586N)238.2Rsp mutation
(0 available)
|
|
|
mortality/aging
nervous system
|
|
• exibit periodic spontaneous epileptic seizures that start at P14/15
|
|
|
• develop neurosclerosis in CA3 subfield
|
|
|
• calcium permeability of AMPA receptors in CA1 pyramidal neurons is increased about 4-fold relative to wild-type
• significant increase in the macroscopic AMPA receptor conductance in nucleated patches of CA1 pyramidal cells
|
behavior/neurological
|
|
• mutants are hyperexcitable
|
|
|
• exibit periodic spontaneous epileptic seizures that start at P14/15
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gria2*586N)238.2Rsp mutation
(0 available)
Tg(SOD1*G93A)1Gur mutation
(4 available)
|
|
|
mortality/aging
|
|
• accelerated disease progression
• decreased survival (1932.93 vs. 208.45.06 days), compared with Tg(SOD1*G93A)1Gur mice
|
growth/size/body
|
|
• declined body weight (14.3% over 51 days) after 20 weeks of age
|
behavior/neurological
|
|
• lose righting reflex between 12 and 18 weeks
|
|
|
• accelerated onset (87.205.5 vs. 1856.3 days), compared with Tg(SOD1*G93A)1Gur mice
• in all 13 mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
growth/size/body
|
|
• decreased body weight from 19 to 83 weeks
|
nervous system
|
|
• neurons in different stages of degeneration and reactive gliosis in the ventromedial hypothalamic nucleus
• decreased density of neurons in the ventromedial hypothalamic nucleus of 12- and 24-month-old mice
|
|
|
• neurons in different stages of degeneration and reactive gliosis in the basolateral amygdaloid nucleus
• decreased density of neurons in the basolateral amygdaloid nucleus of 12- and 24-month-old mice
|
|
|
• reactive gliosis in the ventral horns of lumbar spinal cord, basolateral amygdaloid nucleus, and ventromedial hypothalamic nucleus
|
|
|
• develop late motoneuron degeneration and motoneuron disease
(J:51845)
• neurons in different stages of degeneration in the ventral horns of lumbar spinal cord, basolateral amygdaloid nucleus, and ventromedial hypothalamic nucleus
(J:97818)
• vacuolar structures in the cytoplasm and darkening of the nucleoplasm and cytoplasm in degenerating neurons
(J:97818)
• preservation of synaptic contacts onto degenerating neurons
(J:97818)
|
|
|
• neurons in different stages of degeneration and reactive gliosis in the ventral horns of lumbar spinal cord
|
|
|
• decreased density of neurons in the ventral horns of lumbar spinal cord of 12- and 24-month-old mice
|
|
|
• 2-fold increase in the calcium permeability of AMPA receptors in nucleated CA1 cell patches
|
behavior/neurological
|
|
• anxiety between 19 and 75 weeks of age
• avoid the open arms of the maze, entering them less frequently and spending less time in them
• avoid punished crossings in the four-plate test
|
|
|
• plantar flexion first seen in 33% of the mice at 35 weeks vs 15-25% in wild-type mice at more advanced ages
• plantar flexions are progressively evident in 83% of the mice starting at 47 weeks, and persist up to the age of 83 weeks
• decreased spinal reflexes (H-reflexes and flexor reflexes) at 24 months
|
|
|
• decreased horizontal exploratory activity between 47 and 83 weeks
• move less total distance between 35 and 83 weeks
• lower average speed of movements between 63 and 83 weeks
|
Analysis Tools