Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm3Pkb mutation
(2 available);
any
Ep300 mutation
(97 available)
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mortality/aging
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• adult homozygotes are produced at 50% of the expected frequency; at E18.5 and P0.5, homozygotes are detected at near the expected ratio
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Allelic
Composition |
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300+
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Genetic
Background |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 |
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growth/size/body
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• compound mutants are smaller than littermates
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craniofacial
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• some compound heterozygotes have craniofacial defects
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mortality/aging
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• viable embryos can be recovered at E14.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm3Pkb mutation
(2 available);
any
Ep300 mutation
(97 available)
Tg(IghMyc)22Bri mutation
(1 available)
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neoplasm
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• on a hybrid background presence of a single Ep300tm3Pkb allele decreased the median survival time by about 8-10 weeks compared to wild-type transgenic littermates
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm3Pkb mutation
(2 available);
any
Ep300 mutation
(97 available)
Tg(IghMyc)22Bri mutation
(1 available)
|
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neoplasm
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• on a C57BL/6 background, surivival of transgenic mutants carrying the mutant Ep300 allele were identical to that of Ep300-sufficient transgenic mice
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Analysis Tools
