Analysis Tools
cardiovascular system
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• cross-sectional area of cardiomyocytes is increased more than 2-fold and is present in younger mice
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• heart weight to tibial length is reduced at 6 months of age
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• markers of the fetal gene program and cardiac hypertrophy are upregulated in 6-month-old mice
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• mice develop left ventricular hypertrophy at 6 months of age with pronounced cardiac wall thickening
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• mice show an age-related decrease in fractional shortening and % fractional shortening at 6 moths of age but not in younger mice
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• hypertrophic cardiomyopathy
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cellular
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• mouse embryonic fibroblasts exhibit increased proliferation following stimulation with fetal bovine serum
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craniofacial
broad snout
(
J:296982
)
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• mice have a wider blunted nose
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short snout
(
J:296982
)
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• mice have a wider blunted nose
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growth/size/body
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• markers of the fetal gene program and cardiac hypertrophy are upregulated in 6-month-old mice
|
|
• mice develop left ventricular hypertrophy at 6 months of age with pronounced cardiac wall thickening
|
broad snout
(
J:296982
)
|
• mice have a wider blunted nose
|
short snout
(
J:296982
)
|
• mice have a wider blunted nose
|
|
• mice are slightly smaller, with normal weight but reduced length
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• mice are slightly shorter in length
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muscle
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• cross-sectional area of cardiomyocytes is increased more than 2-fold and is present in younger mice
|
|
• mice develop left ventricular hypertrophy at 6 months of age with pronounced cardiac wall thickening
|
|
• mice show an age-related decrease in fractional shortening and % fractional shortening at 6 moths of age but not in younger mice
|
|
• hypertrophic cardiomyopathy
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vision/eye
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• orbital hypertelorism
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| RASopathy | DOID:0080690 | J:296982 | ||
