Phenotypes associated with this allele

• Allele Symbol: Ptgis^tm1Tada
• Allele Name: targeted mutation 1, Tadashi Tanabe
• Allele ID: MGI:3610729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgis^tm1Tada/Ptgis^tm1Tada	B6.129-Ptgis^tm1Tada	MGI:3611286

Genotype
MGI:3611286

hm1

• Allelic Composition: Ptgis^tm1Tada/Ptgis^tm1Tada
• Genetic Background: B6.129-Ptgis^tm1Tada

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:103380 )

• atrophy, surface irregularities, necrosis, and fibrosis are seen in homozygous kidneys

kidney vascular congestion ( J:103380 )

• restricted occlusions are seen in some small or capillary blood vessels

• thickening of the intimal or medial smooth muscle layers is seen in some arterioles and interlobular, arcuate, and renal arteries resulting in narrowing or blockage of vessels

renal necrosis ( J:103380 )

• necrosis and fibrosis are seen in the medulla and cortex in a deltaic ship

kidney cyst ( J:103380 )

dilated renal glomerular capsule ( J:103380 )

kidney atrophy ( J:103380 )

kidney cortex atrophy ( J:103380 )

• retraction of the renal cortex layer

abnormal renal tubule morphology ( J:103380 )

• shedding of renal tubular cells is seen in the cortex

• restricted occlusions are seen in some renal tubules

renal fibrosis ( J:103380 )

• necrosis and fibrosis are seen in the medulla and cortex in a deltaic ship, with fibrosis also seen along renal tubules and blood vessels

homeostasis/metabolism

increased circulating creatinine level ( J:103380 )

• in 10 week old mice, serum creatinine is increased to 0.61 +/- 0.13 mg/dl compared to 0.502 +/- 0.096 mg/dl in wild-type mice

increased blood urea nitrogen level ( J:103380 )

• in 10 week old mice, BUN is increased to 41.7 +/- 16.0 mg/dl compared to 25.5 +/- 7.3 mg/dl in wild-type mice

decreased prostaglandin level ( J:103380 )

• no detectable 6-keto PGF1alpha (the major hydrolytic product of PGI2) is found in the lungs

increased prostaglandin level ( J:103380 )

• levels of PGE2 are elevated

abnormal thromboxane level ( J:103380 )

• levels of thromboxane B2 (a stable metabolite of TXA2) are elevated 3- to 5-fold in the plasma, kidney and lung

cardiovascular system

abnormal aorta wall morphology ( J:103380 )

abnormal aorta tunica adventitia morphology ( J:103380 )

• in 23-25 week old homozygotes, the adventia of the thoracic aorta is increased in thickness by about 2.2-fold compared to wild-type mice

abnormal aorta tunica media morphology ( J:103380 )

• in 23-25 week old homozygotes, the media of the thoracic aorta is increased in thickness by about 1.3-fold compared to wild-type mice

abnormal thoracic aorta morphology ( J:103380 )

• in 23-25 week old homozygotes, the adventia and media of the thoracic aorta are increased in thickness compared to wild-type mice

kidney vascular congestion ( J:103380 )

• restricted occlusions are seen in some small or capillary blood vessels

• thickening of the intimal or medial smooth muscle layers is seen in some arterioles and interlobular, arcuate, and renal arteries resulting in narrowing or blockage of vessels

increased systemic arterial blood pressure ( J:103380 )

• blood pressure is increased by about 15 mm Hg in 16 week old homozygotes, but is not increased in 10 week old homozygotes

cellular

renal necrosis ( J:103380 )

• necrosis and fibrosis are seen in the medulla and cortex in a deltaic ship

growth/size/body

kidney cyst ( J:103380 )