Ptgis^tm1Tada
Targeted Allele Detail

Summary

• Symbol: Ptgis^tm1Tada
• Name: prostaglandin I2 (prostacyclin) synthase; targeted mutation 1, Tadashi Tanabe
• MGI ID: MGI:3610729
• Synonyms: PGIS^-, PGIS-null, Ptgis^-
• Gene: Ptgis Location: Chr2:167033725-167082524 bp, - strand Genetic Position: Chr2, 87.22 cM, cytoband H3
• Alliance: Ptgis^tm1Tada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103380
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace part of exon 7 and all of exons 8 and 9 with a neomycin resistance gene. RNA blot and immunoblot of mutants failed to detect transcript and protein, respectively, in mutant lungs. (J:103380)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgis Mutation: 36 strains or lines available

References

• Original: J:103380 Yokoyama C, et al., Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation. 2002 Oct 29;106(18):2397-403
• All: 7 reference(s)