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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Angptl3tm1Akos
targeted mutation 1, Anja Koster
MGI:3610614
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Angptl3tm1Akos/Angptl3tm1Akos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3611772
cx2
Angptl3tm1Akos/Angptl3tm1Akos
Angptl4tm1Akos/Angptl4tm1Akos
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3611775


Genotype
MGI:3611772
hm1
Allelic
Composition
Angptl3tm1Akos/Angptl3tm1Akos
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Akos mutation (0 available); any Angptl3 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma cholesterol is significantly lower in fed and fasted states
• in the fed state, both males and females exhibit hypotriglyceridemia
• in the fasted state, females, but not males, exhibit hypotriglyceridemia
• postheparin plasma lipoprotein lipase activity is about 9-fold higher in males under fed conditions and is slightly decreased in the fasted conditions

adipose tissue
N
• no differences from wild-type in body weight or fat or lean mass




Genotype
MGI:3611775
cx2
Allelic
Composition
Angptl3tm1Akos/Angptl3tm1Akos
Angptl4tm1Akos/Angptl4tm1Akos
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Akos mutation (0 available); any Angptl3 mutation (35 available)
Angptl4tm1Akos mutation (0 available); any Angptl4 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• surviving mutants do not survive beyond 2 months of age
• more than half of the mutants exhibit pre- or perinatal mortality

growth/size/body
• surviving mutants are runted

homeostasis/metabolism
• nearly undetectable triglyceride levels





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory