All Phenotypes Nedd4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nedd4⁺
wild type
MGI:3609555

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nedd4^{tm2b(EUCOMM)Hmgu}/Nedd4⁺	C57BL/6N-Nedd4^{tm2b(EUCOMM)Hmgu}/H	MGI:6262997
ht2	Nedd4^Gt(XA209)Byg/Nedd4⁺	involves: 129P2/OlaHsd	MGI:7294431
ht3	Nedd4^{Gt(OST16211)Lex}/Nedd4⁺	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609664
cx4	Grb10^Gt(XC302)Byg/Grb10^Gt(XC302)Byg Nedd4^Gt(XA209)Byg/Nedd4⁺	involves: 129P2/OlaHsd	MGI:7294430

Allelic Composition	Nedd4^{tm2b(EUCOMM)Hmgu}/Nedd4⁺
Genetic Background	C57BL/6N-Nedd4^{tm2b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0814_3_B10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4^{tm2b(EUCOMM)Hmgu} mutation (0 available); any Nedd4 mutation (116 available)

Data Sources

IMPC Data for Nedd4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - HAR

decreased thigmotaxis ( J:211773 )

IMPC - HAR

tremors ( J:211773 )

IMPC - HAR

increased grip strength ( J:211773 )

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - HAR

impaired glucose tolerance ( J:211773 )

IMPC - HAR

immune system

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

Allelic Composition	Nedd4^Gt(XA209)Byg/Nedd4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4^Gt(XA209)Byg mutation (0 available); any Nedd4 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:207675 )

postnatal growth retardation ( J:207675 )

• until 13 weeks of age

decreased fetal weight ( J:207675 )

• at E18.5

Allelic Composition	Nedd4^{Gt(OST16211)Lex}/Nedd4⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4^{Gt(OST16211)Lex} mutation (2 available); any Nedd4 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:103485 )

• mean body weight, total tissue mass, and lean body mass are reduced

Allelic Composition	Grb10^Gt(XC302)Byg/Grb10^Gt(XC302)Byg Nedd4^Gt(XA209)Byg/Nedd4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10^Gt(XC302)Byg mutation (0 available); any Grb10 mutation (56 available)
Nedd4^Gt(XA209)Byg mutation (0 available); any Nedd4 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:207675 )

• no mice are produced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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