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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk11tm1Jsca
targeted mutation 1, J Simon C Arthur
MGI:3609429
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk11tm1Jsca/Mapk11tm1Jsca involves: 129P2/OlaHsd MGI:5288511
hm2
 		Mapk11tm1Jsca/Mapk11tm1Jsca involves: 129P2/OlaHsd * C57BL/6 MGI:3622057
cn3
 		Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5288510
cn4
 		Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5288513
cn5
 		Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5461498
cx6
 		Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+ 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3622058


Genotype
MGI:5288511
hm1
Allelic
Composition		 Mapk11tm1Jsca/Mapk11tm1Jsca
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiac defects in Mapk11tm1Jsca/Mapk11tm1Jsca (p38betaKO), and Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca (dKO) embryos

cardiovascular system
thin right ventricle myocardium compact layer ( J:176023 )
• thinning in the right ventricle with fewer layers in the compact myocardium
increased fetal cardiomyocyte proliferation ( J:176023 )
• increased proliferation at E13.5

muscle
thin right ventricle myocardium compact layer ( J:176023 )
• thinning in the right ventricle with fewer layers in the compact myocardium
increased fetal cardiomyocyte proliferation ( J:176023 )
• increased proliferation at E13.5

cellular
increased fetal cardiomyocyte proliferation ( J:176023 )
• increased proliferation at E13.5




Genotype
MGI:3622057
hm2
Allelic
Composition		 Mapk11tm1Jsca/Mapk11tm1Jsca
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:107771 )
N
• T cell development and LPS-induced cytokine production are similar to wild-type

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:102857 )
N
• glucose tolerance, glucose and insulin levels, and glucose uptake by muscle cells and adipocytes are similar to wild-type




Genotype
MGI:5288510
cn3
Allelic
Composition		 Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Developmental defects in Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca embryos

mortality/aging

nervous system
abnormal neuron proliferation ( J:176023 )
• spina bifida is correlated with neural hyperproliferation
spina bifida ( J:176023 )
• at E13.5
exencephaly ( J:176023 )
• in 30% of mice at E13.5

cardiovascular system
abnormal fetal cardiomyocyte proliferation ( J:176023 )
• decreased proliferation at E13.5

liver/biliary system
abnormal liver morphology ( J:176023 )
• at E13.5 dissociated hepatocytes and infiltration of hematopoietic cells are seen
small liver ( J:176023 )
• at E13.5

reproductive system
primary sex reversal ( J:191096 )
• complete XY sex reversal of gonads at E14.5

muscle
abnormal fetal cardiomyocyte proliferation ( J:176023 )
• decreased proliferation at E13.5

embryo
spina bifida ( J:176023 )
• at E13.5

cellular
abnormal fetal cardiomyocyte proliferation ( J:176023 )
• decreased proliferation at E13.5
abnormal neuron proliferation ( J:176023 )
• spina bifida is correlated with neural hyperproliferation




Genotype
MGI:5288513
cn4
Allelic
Composition		 Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (41 available)
Mapk14tm3.1(Mapk11)Nbr mutation (0 available); any Mapk14 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiac defects in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca embryos

mortality/aging
postnatal lethality, complete penetrance ( J:176023 )
• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

nervous system
nervous system phenotype ( J:176023 )
N
• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14tm3.1(Mapk11)Nbr allele




Genotype
MGI:5461498
cn5
Allelic
Composition		 Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
primary sex reversal ( J:191096 )
• XY sex reversal of gonads at E14.5




Genotype
MGI:3622058
cx6
Allelic
Composition		 Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
ileum inflammation ( J:107771 )
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only
arthritis ( J:107771 )
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only

digestive/alimentary system
ileum inflammation ( J:107771 )
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only

skeleton
arthritis ( J:107771 )
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory