Phenotypes associated with this allele

• Allele Symbol: Pdpk1^tm1Bcol
• Allele Name: targeted mutation 1, Barry J Collins
• Allele ID: MGI:3608995
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdpk1^tm1Bcol/Pdpk1^tm1Bcol	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3609503

Genotype
MGI:3609503

hm1

• Allelic Composition: Pdpk1^tm1Bcol/Pdpk1^tm1Bcol
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:102388 )

• embryos are observed at E19.5, although at reduced mendelian distribution at E16.5 and E19.5, but no postnatal mice are recovered

growth/size/body

decreased embryo size ( J:102388 )

• slight size reduction from E12.5

embryo

decreased embryo size ( J:102388 )

• slight size reduction from E12.5

craniofacial

abnormal craniofacial morphology ( J:102388 )

• exhibit a reduction in cranial tissue at later stages of development (E12.5-E19.5), giving a sharper frontal profile

short mandible ( J:102388 )

• shorter lower jaw at E16.5

limbs/digits/tail

abnormal forelimb morphology ( J:102388 )

• upper limbs have a slack posture characteristic of disuse at E19.5

pigmentation

abnormal eye pigmentation ( J:102388 )

• observed from E12.5

vision/eye

abnormal eye pigmentation ( J:102388 )

• observed from E12.5

skeleton

short mandible ( J:102388 )

• shorter lower jaw at E16.5