Phenotypes associated with this allele

• Allele Symbol: Map3k7^Gt(XB444)Byg
• Allele Name: gene trap XB444, BayGenomics
• Allele ID: MGI:3608889
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k7^Gt(XB444)Byg/Map3k7^Gt(XB444)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3621650
hm2	Map3k7^Gt(XB444)Byg/Map3k7^Gt(XB444)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3621649

Genotype
MGI:3621650

hm1

• Allelic Composition: Map3k7^Gt(XB444)Byg/Map3k7^Gt(XB444)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:102721 )

• die around E10.5 - E11.5

nervous system

open neural tube ( J:102721 )

• at E10 and E10.5, the head fold and neural tube are open and wavy

wavy neural tube ( J:102721 )

• at E10 and E10.5, the head fold and neural tube are open and wavy

embryo

open neural tube ( J:102721 )

• at E10 and E10.5, the head fold and neural tube are open and wavy

wavy neural tube ( J:102721 )

• at E10 and E10.5, the head fold and neural tube are open and wavy

Genotype
MGI:3621649

hm2

• Allelic Composition: Map3k7^Gt(XB444)Byg/Map3k7^Gt(XB444)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107401 )

• die between E10.5 and E11.5

embryo

abnormal pharyngeal arch artery morphology ( J:107401 )

• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous

abnormal vitelline vasculature morphology ( J:107401 )

• at E9.5 in all embryos, the vessels that are present are dilated, in severe cases ruptured, and lack smooth muscle

decreased embryo size ( J:107401 )

• at E9.5, 86% of embryos (class I (31%) and II (55%)) are smaller than normal and the remainder (class III) are similar to wild-type in size and morphology

• at E10.5, 88% of embryos are severely reduced in size and the remainder are mildly reduced in size

embryo tissue necrosis ( J:107401 )

• at E9.5 class I embryos have localized areas of necrosis

abnormal vitelline vascular remodeling ( J:107401 )

• at E9.5 in all embryos, the primary vascular plexus has not been remodeled into a mature vascular network

cardiovascular system

abnormal blood vessel morphology ( J:107401 )

abnormal vascular development ( J:107401 )

abnormal dorsal aorta morphology ( J:107401 )

• at E9.5 in most class II embryos, the anterior dorsal aorta appears collapsed and discontinuous and the posterior dorsal aorta is dilated

• rare cases are found where the anterior dorsal aorta is severely dilated and the posterior dorsal aorta appears normal

• at E10.5, in class III embryos both the anterior and posterior dorsal aorta appear collapsed and in class I and II embryos no recognizable dorsal aorta is seen

abnormal pharyngeal arch artery morphology ( J:107401 )

• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous

abnormal vascular regression ( J:107401 )

• in most embryos the primary capillary plexus of the head is not remodeled into a mature vascular network

• in a few cases partial remodeling of this plexus is seen

abnormal vitelline vasculature morphology ( J:107401 )

• at E9.5 in all embryos, the vessels that are present are dilated, in severe cases ruptured, and lack smooth muscle

abnormal vascular smooth muscle morphology ( J:107401 )

• at E9.5 and E10.5, smooth muscle alpha actin expression is severely reduced or absent

• loose association of smooth muscle cells with the dorsal aorta seen only at E10.5 in some class III embryos

abnormal heart morphology ( J:107401 )

abnormal myocardial trabeculae morphology ( J:107401 )

• at E9.5, areas of the myocardial trabeculae appear thin and disorganized

thin myocardium compact layer ( J:107401 )

• at E9.5 areas in the compact myocardium appear thin and disorganized

small heart ( J:107401 )

• at E9.5

pericardial edema ( J:107401 )

• at E9.5 class I embryos have pericardial edema

• at E10.5, 88% of embryos have large pericardial edemas and the remainder usually have some pericardial edema

hemorrhage ( J:107401 )

• at E9.5, in severe cases ruptured vessels and bleeding are seen in the yolk sac

homeostasis/metabolism

edema ( J:107401 )

• at E9.5, occasional class II have small edemas

• at E10.5, some embryos with pericardial edema also have edema along the body wall

pericardial edema ( J:107401 )

• at E9.5 class I embryos have pericardial edema

• at E10.5, 88% of embryos have large pericardial edemas and the remainder usually have some pericardial edema

craniofacial

abnormal pharyngeal arch artery morphology ( J:107401 )

• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous

limbs/digits/tail

short tail ( J:107401 )

• at E9.5 class I embryos have a truncated, curved tail

growth/size/body

decreased embryo size ( J:107401 )

• at E9.5, 86% of embryos (class I (31%) and II (55%)) are smaller than normal and the remainder (class III) are similar to wild-type in size and morphology

• at E10.5, 88% of embryos are severely reduced in size and the remainder are mildly reduced in size

microcephaly ( J:107401 )

• at E9.5 class I embryos have small heads

muscle

abnormal vascular smooth muscle morphology ( J:107401 )

• at E9.5 and E10.5, smooth muscle alpha actin expression is severely reduced or absent

• loose association of smooth muscle cells with the dorsal aorta seen only at E10.5 in some class III embryos

abnormal myocardial trabeculae morphology ( J:107401 )

• at E9.5, areas of the myocardial trabeculae appear thin and disorganized

thin myocardium compact layer ( J:107401 )

• at E9.5 areas in the compact myocardium appear thin and disorganized

cellular

abnormal vascular regression ( J:107401 )

• in most embryos the primary capillary plexus of the head is not remodeled into a mature vascular network

• in a few cases partial remodeling of this plexus is seen