Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7Gt(XB444)Byg mutation
(0 available);
any
Map3k7 mutation
(51 available)
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mortality/aging
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• die around E10.5 - E11.5
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nervous system
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• at E10 and E10.5, the head fold and neural tube are open and wavy
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• at E10 and E10.5, the head fold and neural tube are open and wavy
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embryo
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• at E10 and E10.5, the head fold and neural tube are open and wavy
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• at E10 and E10.5, the head fold and neural tube are open and wavy
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7Gt(XB444)Byg mutation
(0 available);
any
Map3k7 mutation
(51 available)
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mortality/aging
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• die between E10.5 and E11.5
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embryo
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• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous
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• at E9.5 in all embryos, the vessels that are present are dilated, in severe cases ruptured, and lack smooth muscle
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• at E9.5 class I embryos have localized areas of necrosis
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• at E9.5, 86% of embryos (class I (31%) and II (55%)) are smaller than normal and the remainder (class III) are similar to wild-type in size and morphology
• at E10.5, 88% of embryos are severely reduced in size and the remainder are mildly reduced in size
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• at E9.5 in all embryos, the primary vascular plexus has not been remodeled into a mature vascular network
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cardiovascular system
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• at E9.5 in most class II embryos, the anterior dorsal aorta appears collapsed and discontinuous and the posterior dorsal aorta is dilated
• rare cases are found where the anterior dorsal aorta is severely dilated and the posterior dorsal aorta appears normal
• at E10.5, in class III embryos both the anterior and posterior dorsal aorta appear collapsed and in class I and II embryos no recognizable dorsal aorta is seen
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• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous
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• in most embryos the primary capillary plexus of the head is not remodeled into a mature vascular network
• in a few cases partial remodeling of this plexus is seen
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• at E9.5 in all embryos, the vessels that are present are dilated, in severe cases ruptured, and lack smooth muscle
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• at E9.5 and E10.5, smooth muscle alpha actin expression is severely reduced or absent
• loose association of smooth muscle cells with the dorsal aorta seen only at E10.5 in some class III embryos
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• at E9.5, areas of the myocardial trabeculae appear thin and disorganized
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• at E9.5 areas in the compact myocardium appear thin and disorganized
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• at E9.5 class I embryos have pericardial edema
• at E10.5, 88% of embryos have large pericardial edemas and the remainder usually have some pericardial edema
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• at E9.5, in severe cases ruptured vessels and bleeding are seen in the yolk sac
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homeostasis/metabolism
craniofacial
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• at E9.5 in class II embryos, the branchial arch arteries appear collapsed and discontinuous
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limbs/digits/tail
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• at E9.5 class I embryos have a truncated, curved tail
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growth/size/body
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• at E9.5, 86% of embryos (class I (31%) and II (55%)) are smaller than normal and the remainder (class III) are similar to wild-type in size and morphology
• at E10.5, 88% of embryos are severely reduced in size and the remainder are mildly reduced in size
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• at E9.5 class I embryos have small heads
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muscle
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• at E9.5 and E10.5, smooth muscle alpha actin expression is severely reduced or absent
• loose association of smooth muscle cells with the dorsal aorta seen only at E10.5 in some class III embryos
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• at E9.5, areas of the myocardial trabeculae appear thin and disorganized
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• at E9.5 areas in the compact myocardium appear thin and disorganized
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cellular
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• in most embryos the primary capillary plexus of the head is not remodeled into a mature vascular network
• in a few cases partial remodeling of this plexus is seen
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• at E9.5 class I embryos have localized areas of necrosis
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Analysis Tools