Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-Agt)2Mte
• Allele Name: transgene insertion 2, Michele Teboul
• Allele ID: MGI:3608886
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Agt^tm1Afu/Agt^tm1Afu Tg(Fabp4-Agt)2Mte/0	involves: C57BL/6 * CBA * DBA/2 * ICR	MGI:3609055
tg2	Tg(Fabp4-Agt)2Mte/0	involves: C57BL/6 * CD-1 * DBA/2 * ICR	MGI:3609050

Genotype
MGI:3609055

cx1

• Allelic Composition: Agt^tm1Afu/Agt^tm1Afu; Tg(Fabp4-Agt)2Mte/0
• Genetic Background: involves: C57BL/6 * CBA * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating angiotensinogen level ( J:73163 )

• plasma angiotensinogen levels are 20-30% of those in wild-type even though transgene expression rescues the Agt mutant phenotype and mutants are normotensive

Genotype
MGI:3609050

tg2

• Allelic Composition: Tg(Fabp4-Agt)2Mte/0
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2 * ICR

adipose tissue

increased total body fat amount ( J:73163 )

• higher total fat mass, epididymal fat pad weight, and adiposity index than in wild-type

abnormal fat cell morphology ( J:73163 )

• adipocyte hypoplasia

increased fat cell size ( J:73163 )

• increase in cell diameter and weight

increased epididymal fat pad weight ( J:73163 )

• increase in epididymal fat pad weight

cardiovascular system

increased systemic arterial systolic blood pressure ( J:73163 )

growth/size/body

increased body weight ( J:73163 )

• significantly greater body weight than wild-type

homeostasis/metabolism

abnormal blood homeostasis ( J:73163 )

• plasma angiotensinogen levels are increased (from 22 to 44%) compared to wild-type

decreased circulating renin level ( J:73163 )

• lower plasma renin activity

behavior/neurological

decreased locomotor activity ( J:73163 )

• locomotor activity in the daytime is slightly lower than in wild-type