Analysis Tools
mortality/aging
nervous system
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• neural crest cells are absent from the gut anlage at E11 - E11.5 and from the gut at E12.5 - E13.5 suggesting a failure of these cells to colonize the anlage of the stomach and intestine
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• enteric ganglia are present around the cardiac stomach but severely reduced or absent in more caudal gastric regions and throughout the intestine
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digestive/alimentary system
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• absence of milk in the intestine suggests impaired gastrointestinal peristalsis
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renal/urinary system
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• kidneys lack a recognizable medulla, cortex, and nephrogenic zone and have large regions of undifferentiated mesenchyme
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• kidneys are severely hypoplastic with very few recognizable nephric elements
this phenotype is similar but not as severe as in homozygous Ret null mice
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• at E12.5 - E13.5 the number of ureteric bud tips is severely reduced
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embryo
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• neural crest cells are absent from the gut anlage at E11 - E11.5 and from the gut at E12.5 - E13.5 suggesting a failure of these cells to colonize the anlage of the stomach and intestine
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muscle
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• absence of milk in the intestine suggests impaired gastrointestinal peristalsis
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