All Phenotypes sau MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

sau
sauron
MGI:3607721

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxq1^sa/Foxq1⁺ sau/sau⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607722
cx2	sau/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607793

Allelic Composition	Foxq1^sa/Foxq1⁺ sau/sau⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:101156 )

• heterozygous mice exhibit heightened anxiety in the Open Field Activity test, entering the center of the field 29% less frequently than littermate controls

Allelic Composition	sau/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:101156 )

• hemizygous progeny are born at less than one-third the expected Mendelian frequency, most dying by 16.5 days post coitum (16.5 dpc)

nervous system

holoprosencephaly ( J:101156 )

• hemizygous embyros examined at 9.5 dpc often exhibit midline forebrain defects and other aspects of holoprocencephaly

• some hemizygotes that survive to birth exhibit holoprosencephalic phenotypes of varying severity

vision/eye

abnormal eye development ( J:101156 )

• some hemizygous embryos and liveborn pups exhibit structural eye defects

cyclopia ( J:101156 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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