Phenotypes associated with this allele

• Allele Symbol: Cpeb1^tm1Rcht
• Allele Name: targeted mutation 1, Joel D Richter
• Allele ID: MGI:3606747
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpeb1^tm1Rcht/Cpeb1^tm1Rcht	involves: 129S7/SvEvBrd * C57BL/6	MGI:3607702

Genotype
MGI:3607702

hm1

• Allelic Composition: Cpeb1^tm1Rcht/Cpeb1^tm1Rcht
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased male germ cell apoptosis ( J:102097 )

♂ • increased apoptosis of pachytene spermatocytes

abnormal reproductive system morphology ( J:102097 )

abnormal ovary development ( J:102097 )

♀ • ovary size is normal through E18.5 but diplotene oocytes are found

♀ • adult mice have vestigial ovaries

absent ovary ( J:102097 )

♀ • ovaries are absent or vestigial in the adult

decreased testis weight ( J:102097 )

♂ • 30% smaller than controls

♂ • weight difference starting at 23 days and continuing through 77 days of age

abnormal gametogenesis ( J:102097 )

oligozoospermia ( J:102097 )

♂ • 6 fold fewer sperm than in controls and only 2% are motile

abnormal female meiosis ( J:102097 )

♀ • E14.5 oocytes show meiotic arrest at pachytene; diplotene oocytes undetectable at E18.5

♀ • DNA highly fragmented and dispersed in oocytes at E16.5

arrest of male meiosis ( J:102097 )

♂ • pachytene spermatocytes undetectable at 16 days of age

abnormal fertility/fecundity ( J:102097 )

female infertility ( J:102097 )

♀ • no offspring from matings to wild-type males

reduced male fertility ( J:102097 )

♂ • only 20% of matings to wild-type females produced offspring

nervous system

abnormal long-term potentiation ( J:101987 )

• single stimulus long-term potentiation defective

• effect seen only with weak stimuli

endocrine/exocrine glands

abnormal ovary development ( J:102097 )

♀ • ovary size is normal through E18.5 but diplotene oocytes are found

♀ • adult mice have vestigial ovaries

absent ovary ( J:102097 )

♀ • ovaries are absent or vestigial in the adult

decreased testis weight ( J:102097 )

♂ • 30% smaller than controls

♂ • weight difference starting at 23 days and continuing through 77 days of age

cellular

oligozoospermia ( J:102097 )

♂ • 6 fold fewer sperm than in controls and only 2% are motile

increased male germ cell apoptosis ( J:102097 )

♂ • increased apoptosis of pachytene spermatocytes