Phenotypes associated with this allele

• Allele Symbol: Mctp1⁺
• Allele Name: wild type
• Allele ID: MGI:3605680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mctp1^dwnd/Nr2f1^tm1.1(KOMP)Mbp	involves: C57BL/6J * C57BL/6NJ * C57BL/10SnJ	MGI:6197582

Genotype
MGI:6197582

cx1

• Allelic Composition: Mctp1^dwnd/Nr2f1^{tm1.1(KOMP)Mbp}
• Genetic Background: involves: C57BL/6J * C57BL/6NJ * C57BL/10SnJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell morphology ( J:264553 )

• basal cochlea has disorganized hair cells and an excess of inner hair cells, and the apex has extra rows of outer hair cells

abnormal cochlear inner hair cell morphology ( J:264553 )

abnormal cochlear outer hair cell morphology ( J:264553 )

short scala media ( J:264553 )

abnormal utricular macula morphology ( J:264553 )

• the utricular macula is reduced from an ovate to a trapezoid shape

abnormal vestibular saccular macula morphology ( J:264553 )

• the saccular macula is often attached to the utricular macula and cochlear base

fused vestibular saccule and utricle ( J:264553 )

• the utricle and saccule fail to properly separate

increased or absent threshold for auditory brainstem response ( J:264553 )

• transheterozygotes have ABR thresholds 25-50 dB higher than controls at 1 month of age

impaired hearing ( J:264553 )

nervous system

abnormal cochlear hair cell morphology ( J:264553 )

• basal cochlea has disorganized hair cells and an excess of inner hair cells, and the apex has extra rows of outer hair cells

abnormal cochlear inner hair cell morphology ( J:264553 )

abnormal cochlear outer hair cell morphology ( J:264553 )