Analysis Tools
normal phenotype
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• viable, fertile, and lack gross morphological or behavioral abnormalities
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Allele Symbol Allele Name Allele ID |
Efna3tm1Rax targeted mutation 1, Richard Axel MGI:3605006 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, fertile, and lack gross morphological or behavioral abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• diminished survival to weaning but sufficient survivors for study
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• females fail to nurse young
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• SR1 glomeruli shifted posteriorly by about 20% of the length of the bulb and slightly ventrally on the medial aspect
• P2 glomeruli shifted somewhat posteriorly and shifted dorsally on the medial aspect
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• localization of innervations from the optic nerve to the dorsal lateral geniculate body are defective
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants do not exhibit deficits in cue-related or context-related fear conditioning, but time spent freezing remains increased for all testing 24 hours after conditioning
• mutants exhibit a different swim pattern than wild-type mice in the Morris water maze, with a tendency to exhibit small spiral swim patterns along the wall of the pool interrupted by bursts of random swimming that criss-cross the maze compared to wild-type mice that show a combination of large circular swim patterns interspersed with some cross-maze swimming
• in the probe trail, mutants, but not wild-type mice, tend to revert back to their swim patterns during early training
• however, mutants are able to learn the new location of the hidden quadrant during reversal training of the Morris water maze
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• although mutants exhibit a normal exploratory response to a novel environment, they engage in exploratory behavior less in the second 10 min of testing than wild-type mice, engaging mostly in grooming behaviors during the non-exploratory time
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• mutants bury fewer marbles than wild-type mice
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• mutants exhibit increased thigmotaxis in the open field
• however, mice show similar behavior as wild-type mice in the elevated plus maze
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• mutants exhibit compulsive facial grooming that becomes apparent around 3 months of age and increases in severity over time, leading to hair loss or skin lesions at site of over-grooming between 4-6 months of age
• mutants engage in exploratory behavior less the second 10 min of testing than wild-type mice, engaging mostly in grooming behaviors during the non-exploratory time
• mutants spend more time grooming during the 5 minutes after receiving a facial spritz of water
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• mutants exhibit an attenuated auditory startle compared to wild-type mice on the trials without prepulses
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• mutants rear fewer times than wild-type mice
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• in the open field, mutants travel less distance than wild-type mice
• mutants are hypolocomotive and this hypoactivity does not change over time, however, the decline in exploratory activity is similar to wild-type mice
• however, mice exhibit normal gait and ambulatory coordination
• in the three-chamber social behavior assay, mutants show less spontaneous locomotor activity
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• in the three-chamber social behavior assay, mutants show a social aversion, with social index values less than in wild-type mice
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• abrasive lesions around the eyes due to excessive grooming are nearly always more severe on the side where the ear tag is placed, suggesting sensorimotor gating problems
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• mutants have greater prepulse inhibition (PPI) of acoustic startle response than wild-type mice at all prepulse intensities (3 dB, 6 dB, and 12 dB) tested and there is a greater percent increase in PPI with increasing prepulse intensities
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:216970 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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