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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grik5tm1Dgen
targeted mutation 1, Deltagen
MGI:3604589
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grik5tm1Dgen/Grik5tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606461


Genotype
MGI:3606461
hm1
Allelic
Composition		 Grik5tm1Dgen/Grik5tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik5tm1Dgen mutation (1 available); any Grik5 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:101679 )
• a lower dose of metrazol is needed to induce tonic/clonic seizure
increased startle reflex ( J:101679 )
• startle responses to acoustic stimuli are increased in the startle prepulse inhibition test
increased thermal nociceptive threshold ( J:101679 )
• response latency to an acute thermal stimulus in the Tail flick test is increased

nervous system
increased susceptibility to pharmacologically induced seizures ( J:101679 )
• a lower dose of metrazol is needed to induce tonic/clonic seizure




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory