Analysis Tools
behavior/neurological
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• instrumental-conditioning is reduced compared to in wild-type mice that acquire the bar-pressing response to obtain food faster and reach higher asymptotic performance after more extensive training
• however, sensitivity to devaluation in instrumental conditioning remains normal and appetite motivated response to auditory cued conditioning is normal
• mice are more sensitive to devaluation than wild-type mice in an auditory cued conditioning experiment
• under a progressive ratio 5 schedule, mice respond at higher rates and earn more food reward than wild-type mice and in omission testing mice continue to press the level compared to wild-type mice that stop
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nervous system
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• plasma membrane extracts from the striatum contain 55% less cAMP that in wild-type mice
• however, forskolin-induced camp production is normal
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