All Phenotypes Rgs4<tm1Dgen> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rgs4^tm1Dgen
targeted mutation 1, Deltagen
MGI:3604580

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs4^tm1Dgen/Rgs4^tm1Dgen	B6.129P2-Rgs4^tm1Dgen	MGI:4950024
hm2	Rgs4^tm1Dgen/Rgs4^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606563
cx3	Fmr1^tm1Cgr/Fmr1^tm1Cgr Rgs4^tm1Dgen/Rgs4^tm1Dgen	B6.129P2-Rgs4^tm1Dgen Fmr1^tm1Cgr	MGI:4950025
cx4	Reln^ctrdel/Reln^ctrdel Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505413
cx5	m2Bei/m2Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505419
cx6	m3Bei/m3Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505435
cx7	Dnaaf1^m4Bei/Dnaaf1^m4Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505452
cx8	m5Bei/m5Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505453
cx9	Drc3^m6Bei/Drc3^m6Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505455

Allelic Composition	Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	B6.129P2-Rgs4^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:171292 )

N	• mice exhibit normal novel object recognition

impaired conditioned place preference behavior ( J:171292 )

• for a scent-paired chamber

decreased aggression towards mice ( J:171292 )

• mice exhibit less social dominance compared with wild-type mice

hyperactivity ( J:171292 )

increased vertical activity ( J:171292 )

Allelic Composition	Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:101679 )

• 3 of 6 homozygotes at 49 days of age exhibit a high fat percentage

homeostasis/metabolism

increased circulating cholesterol level ( J:101679 )

• homozygous males have increased levels of cholesterol

increased circulating HDL cholesterol level ( J:101679 )

• homozygous males have increased levels of high density lipoprotein

Allelic Composition	Fmr1^tm1Cgr/Fmr1^tm1Cgr Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	B6.129P2-Rgs4^tm1Dgen Fmr1^tm1Cgr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1^tm1Cgr mutation (5 available); any Fmr1 mutation (30 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased testis weight ( J:171292 )

behavior/neurological

behavior/neurological phenotype ( J:171292 )

N	• mice exhibit normal social dominance and conditioned place preference

abnormal object recognition memory ( J:171292 )

• mice exhibit reduced novel object recognition compared with wild-type mice

hyperactivity ( J:171292 )

increased vertical activity ( J:171292 )

growth/size/body

growth/size/body region phenotype ( J:171292 )

N	• mice exhibit normal weight

endocrine/exocrine glands

increased testis weight ( J:171292 )

Allelic Composition	Reln^ctrdel/Reln^ctrdel Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^ctrdel mutation (0 available); any Reln mutation (209 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:199782 )

N	• no cerebellar defects

abnormal stratification in cerebral cortex ( J:199782 )

• layers II, II, IV, V cannot be distinguished

• brains are otherwise normal

Allelic Composition	m2Bei/m2Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m2Bei mutation (0 available); any m2Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:199782 )

enlarged lateral ventricles ( J:199782 )

abnormal stratification in cerebral cortex ( J:199782 )

• superficial layers are thinner

Allelic Composition	m3Bei/m3Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m3Bei mutation (0 available); any m3Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:199782 )

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal cerebral cortex morphology ( J:199782 )

• anterior cortex is sometimes narrow

abnormal stratification in cerebral cortex ( J:199782 )

• superficial layers are thinner

• layers II, III, IV are disturbed

small olfactory bulb ( J:199782 )

Allelic Composition	Dnaaf1^m4Bei/Dnaaf1^m4Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaaf1^m4Bei mutation (1 available); any Dnaaf1 mutation (32 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• posteriorly displaced

small hippocampus ( J:199782 )

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Allelic Composition	m5Bei/m5Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m5Bei mutation (0 available); any m5Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• small

• posteriorly displaced

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Allelic Composition	Drc3^m6Bei/Drc3^m6Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drc3^m6Bei mutation (1 available); any Drc3 mutation (25 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• posteriorly displaced

small hippocampus ( J:199782 )

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/07/2025 MGI 6.24