All Phenotypes Rgs4<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rgs4^tm1Dgen
targeted mutation 1, Deltagen
MGI:3604580

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs4^tm1Dgen/Rgs4^tm1Dgen	B6.129P2-Rgs4^tm1Dgen	MGI:4950024
hm2	Rgs4^tm1Dgen/Rgs4^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606563
cx3	Fmr1^tm1Cgr/Fmr1^tm1Cgr Rgs4^tm1Dgen/Rgs4^tm1Dgen	B6.129P2-Rgs4^tm1Dgen Fmr1^tm1Cgr	MGI:4950025
cx4	Reln^ctrdel/Reln^ctrdel Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505413
cx5	m2Bei/m2Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505419
cx6	m3Bei/m3Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505435
cx7	Dnaaf1^m4Bei/Dnaaf1^m4Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505452
cx8	m5Bei/m5Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505453
cx9	Drc3^m6Bei/Drc3^m6Bei Rgs4^tm1Dgen/Rgs4⁺	involves: 129P2/OlaHsd * A/J * C57BL/6	MGI:5505455

Allelic Composition	Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	B6.129P2-Rgs4^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:171292 )

N	• mice exhibit normal novel object recognition

impaired conditioned place preference behavior ( J:171292 )

• for a scent-paired chamber

decreased aggression towards mice ( J:171292 )

• mice exhibit less social dominance compared with wild-type mice

hyperactivity ( J:171292 )

increased vertical activity ( J:171292 )

Allelic Composition	Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:101679 )

• 3 of 6 homozygotes at 49 days of age exhibit a high fat percentage

homeostasis/metabolism

increased circulating cholesterol level ( J:101679 )

• homozygous males have increased levels of cholesterol

increased circulating HDL cholesterol level ( J:101679 )

• homozygous males have increased levels of high density lipoprotein

Allelic Composition	Fmr1^tm1Cgr/Fmr1^tm1Cgr Rgs4^tm1Dgen/Rgs4^tm1Dgen
Genetic Background	B6.129P2-Rgs4^tm1Dgen Fmr1^tm1Cgr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1^tm1Cgr mutation (5 available); any Fmr1 mutation (28 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased testis weight ( J:171292 )

behavior/neurological

behavior/neurological phenotype ( J:171292 )

N	• mice exhibit normal social dominance and conditioned place preference

abnormal object recognition memory ( J:171292 )

• mice exhibit reduced novel object recognition compared with wild-type mice

hyperactivity ( J:171292 )

increased vertical activity ( J:171292 )

growth/size/body

growth/size/body region phenotype ( J:171292 )

N	• mice exhibit normal weight

endocrine/exocrine glands

increased testis weight ( J:171292 )

Allelic Composition	Reln^ctrdel/Reln^ctrdel Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^ctrdel mutation (0 available); any Reln mutation (209 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:199782 )

N	• no cerebellar defects

abnormal stratification in cerebral cortex ( J:199782 )

• layers II, II, IV, V cannot be distinguished

• brains are otherwise normal

Allelic Composition	m2Bei/m2Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m2Bei mutation (0 available); any m2Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:199782 )

enlarged lateral ventricles ( J:199782 )

abnormal stratification in cerebral cortex ( J:199782 )

• superficial layers are thinner

Allelic Composition	m3Bei/m3Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m3Bei mutation (0 available); any m3Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:199782 )

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal cerebral cortex morphology ( J:199782 )

• anterior cortex is sometimes narrow

abnormal stratification in cerebral cortex ( J:199782 )

• superficial layers are thinner

• layers II, III, IV are disturbed

small olfactory bulb ( J:199782 )

Allelic Composition	Dnaaf1^m4Bei/Dnaaf1^m4Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaaf1^m4Bei mutation (1 available); any Dnaaf1 mutation (32 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• posteriorly displaced

small hippocampus ( J:199782 )

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Allelic Composition	m5Bei/m5Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m5Bei mutation (0 available); any m5Bei mutation (0 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• small

• posteriorly displaced

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Allelic Composition	Drc3^m6Bei/Drc3^m6Bei Rgs4^tm1Dgen/Rgs4⁺
Genetic Background	involves: 129P2/OlaHsd * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drc3^m6Bei mutation (1 available); any Drc3 mutation (25 available)
Rgs4^tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:199782 )

• postnatal lethality in the third week sometimes

nervous system

enlarged lateral ventricles ( J:199782 )

• ventriculomegaly

abnormal hippocampus morphology ( J:199782 )

• posteriorly displaced

small hippocampus ( J:199782 )

thin cerebral cortex ( J:199782 )

• severe cortical thinning

craniofacial

domed cranium ( J:199782 )

• domed heads sometimes

skeleton

domed cranium ( J:199782 )

• domed heads sometimes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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