Phenotypes associated with this allele

• Allele Symbol: Slc22a12^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604569
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc22a12^tm1Dgen/Slc22a12^tm1Dgen	B6.129P2-Slc22a12^tm1Dgen	MGI:3798164
hm2	Slc22a12^tm1Dgen/Slc22a12^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606623

Genotype
MGI:3798164

hm1

• Allelic Composition: Slc22a12^tm1Dgen/Slc22a12^tm1Dgen
• Genetic Background: B6.129P2-Slc22a12^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:136005 )

• urine metabolite composition is altered compared to in wild-type mice

• however, plasma urate levels are normal

uraturia ( J:136005 )

• urate fractional excretion is increased compared to in wild-type mice

• the level of urinary urate is 2-fold higher than in wild-type mice

homeostasis/metabolism

abnormal blood homeostasis ( J:136005 )

• plasma metabolite composition is altered compared to in wild-type mice

abnormal urine homeostasis ( J:136005 )

• urine metabolite composition is altered compared to in wild-type mice

• however, plasma urate levels are normal

uraturia ( J:136005 )

• urate fractional excretion is increased compared to in wild-type mice

• the level of urinary urate is 2-fold higher than in wild-type mice

Genotype
MGI:3606623

hm2

• Allelic Composition: Slc22a12^tm1Dgen/Slc22a12^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:101679 )

N • normal

behavior/neurological

behavior/neurological phenotype ( J:101679 )

N • normal

cardiovascular system

cardiovascular system phenotype ( J:101679 )

N • normal

digestive/alimentary system

digestive/alimentary phenotype ( J:101679 )

N • normal

growth/size/body

growth/size/body region phenotype ( J:101679 )

N

hematopoietic system

hematopoietic system phenotype ( J:101679 )

N • normal

nervous system

nervous system phenotype ( J:101679 )

N • normal

reproductive system

reproductive system phenotype ( J:101679 )

N • normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:101679 )

N • normal