All Phenotypes Cacna1c<tm1Dgen> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cacna1c^tm1Dgen
targeted mutation 1, Deltagen
MGI:3604527

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1c^tm1Dgen/Cacna1c^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606690
ht2	Cacna1c^tm1Dgen/Cacna1c⁺	B6.129P2-Cacna1c^tm1Dgen/J	MGI:5910272
ht3	Cacna1c^tm1Dgen/Cacna1c⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3606691

Allelic Composition	Cacna1c^tm1Dgen/Cacna1c^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1c^tm1Dgen mutation (1 available); any Cacna1c mutation (152 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:101679 )

• no homozygotes identified at weaning

Allelic Composition	Cacna1c^tm1Dgen/Cacna1c⁺
Genetic Background	B6.129P2-Cacna1c^tm1Dgen/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1c^tm1Dgen mutation (1 available); any Cacna1c mutation (152 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal mandible morphology ( J:197612 )

• adult mandibles show reduced width between coronoid processes

growth/size/body

growth/size/body region phenotype ( J:197612 )

N	• overall size, weight and tibial length is not different

abnormal mandible morphology ( J:197612 )

• adult mandibles show reduced width between coronoid processes

skeleton

abnormal mandible morphology ( J:197612 )

• adult mandibles show reduced width between coronoid processes

Allelic Composition	Cacna1c^tm1Dgen/Cacna1c⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1c^tm1Dgen mutation (1 available); any Cacna1c mutation (152 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:101679 )

• avoid central areas in open field tests

impaired coordination ( J:101679 )

• significantly poorer performance on a rotarod test

decreased locomotor activity ( J:101679 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24