Phenotypes associated with this allele

• Allele Symbol: Adipor1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604517
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipor1^tm1Dgen/Adipor1^tm1Dgen	B6.129P2-Adipor1^tm1Dgen/Mmnc	MGI:3713860
hm2	Adipor1^tm1Dgen/Adipor1^tm1Dgen	involves: 129P2/OlaHsd	MGI:6106866
hm3	Adipor1^tm1Dgen/Adipor1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606562

Genotype
MGI:3713860

hm1

• Allelic Composition: Adipor1^tm1Dgen/Adipor1^tm1Dgen
• Genetic Background: B6.129P2-Adipor1^tm1Dgen/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating leptin level ( J:122027 )

decreased energy expenditure ( J:122027 )

• during light and dark phase, energy expenditure is decreased

• however, respiratory exchange ratio is unchanged

impaired glucose tolerance ( J:122027 )

• male mice have a 35% higher glucose response than in wild-type mice

abnormal lipid homeostasis ( J:122027 )

increased circulating cholesterol level ( J:122027 )

• females have increased plasma cholesterol

increased liver triglyceride level ( J:122027 )

• liver triglyceride levels are increased

adipose tissue

increased brown adipose tissue amount ( J:122027 )

• in males and females at 31 weeks

increased white adipose tissue amount ( J:122027 )

• in males and females at 31 weeks

increased percent body fat/body weight ( J:122027 )

behavior/neurological

decreased locomotor activity ( J:122027 )

• mice have decreased spontaneous locomotor activity and more time spent in corners of the cages

growth/size/body

increased susceptibility to weight gain ( J:122027 )

• males, but not females, have increased body weight despite similar food intake as wild-type controls

liver/biliary system

increased liver triglyceride level ( J:122027 )

• liver triglyceride levels are increased

Genotype
MGI:6106866

hm2

• Allelic Composition: Adipor1^tm1Dgen/Adipor1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:210480 )

• mice treated with isopropanol exhibit less of an increase in interscapular brown adipose tissue compared with similarly treated wild-type mice

impaired adaptive thermogenesis ( J:210480 )

• cold-exposed mice exhibit lower core body temperatures compared with similarly treated wild-type mice

• however, deletion of adiponectin restored cold-adaptation

decreased adiponectin level ( J:210480 )

• in serum and interscapular brown adipose tissue

decreased circulating adiponectin level ( J:210480 )

Genotype
MGI:3606562

hm3

• Allelic Composition: Adipor1^tm1Dgen/Adipor1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:101679 )