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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Txndc2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3604412
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Txndc2tm1Lex/Txndc2tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609916


Genotype
MGI:3609916
hm1
Allelic
Composition		 Txndc2tm1Lex/Txndc2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txndc2tm1Lex mutation (2 available); any Txndc2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body size ( J:103485 )
increased body weight ( J:103485 )
increased body length ( J:103485 )
• exhibit increased mean body weight, length, total tissue mass, and lean body mass

homeostasis/metabolism
abnormal circulating phosphate level ( J:103485 )
• increase in mean serum phosphorus level
decreased circulating interleukin-6 level ( J:103485 )
• exhibit a decreased serum IL-6 response to LPS challenge

immune system
decreased circulating interleukin-6 level ( J:103485 )
• exhibit a decreased serum IL-6 response to LPS challenge




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory